PURPOSE: To rapidly obtain alcohols useful as a synthetic intermediate for medicines, etc., in high yield under mild conditions by reducing a carboxylic acid using a borane-pyridine complex as a reducing agent in the coexistence of a Lewis acid and a trialkoxyborane.NISHIHARA NORIO...
The purpose of this chapter is to give the reader an overview of these methods by subdividing the chapter into the various common carboxylic acid derivatives (acids, esters, amides, etc.). The methods are then discussed within these contexts, with a goal of highlighting their positive and ...
262-266, " Reduction of Dicarboxylic Acid Anhydride With 2-Propanol Over Hydrous Zirconium Oxide ", 1992.Takahashi Kyoko, Shibagaki Makoto, Kuno Kideyuki, etc.Reduction of carboxylic acid with 2-propanol over hydrous zirconium oxide[J]. Chem. Lett., 1989, (7): 1141-1144....
Reduction of carboxylic acid into alcohols using NaBH4 in the presence of catechol and/or CF3COOH [J]. Tetrahedron, 1992,48(2):371-376.Suseela, Y,Periasamy, M.Reduction of carboxylic acids into alcohols using NaBH4 in the presence of catechol and/or CF3COOH. Tetrahedron . 1992...
Carboxylic acids were immediately reduced with samarium diiodide in the presence of protic solvent under the basic medium at room temperature to the corresponding alcohols in good yields. The similar reaction of sodium benzoate in the absence of protic solvent afforded the reductive carbon-carbon coupli...
Carboxylic acid reductases (CARs) selectively reduce carboxylic acids to aldehydes using ATP and NADPH as cofactors under mild conditions. Although CARs attracts significant interest, only a few enzymes have been characterized to date, whereas the vast majority of CARs have yet to be examined. Herei...
In the presence of a tertiary amine, sodium borohydride (NaBH4) combined with zinc chloride (ZnCl2) showed powerful reducing properties and carboxylic esters were smoothly reduced to their corresponding alcohols which were not obtained by reduction with NaBH4 and ZnCl2 alone. Tetrahydrofuran (THF) was...
Synthesis of Ethers by GaBr3‐Catalyzed Reduction of Carboxylic Acid Esters and Lactones by Siloxanes Ethers were synthesized by reduction of the respective esters catalyzed by gallium bromide (GaBr3) and using siloxanes, preferentially 1,1,3,3-tetramethyld... U Biermann,JO Metzger - 《Chemsuschem...
The reduction was performed in whole Escherichia coli BL21 (DE3) cells overexpressing carboxylic acid reductase from Nocardia and phosphopantetheinyl transferase from E.coli. An endogenous E.coli aldehyde reducing activity turned out to be highly efficient for further reduction of the aldehyde intermediate...
There is continuously supplied to the reactor a substrate stream which contains 50 to 100% of the maximum amount soluble, but not over 2,000 mmol/l, of the reacting α-ketocarboxylic acid in the form of a water soluble salt and 100 to 6,000 mmol/l of a formate. There is maintained ...