Accurate investigations on the role played by an #alpha#-stereogenic center in controlling the reduction of various classes of #beta#-hydroxy ketones allowed us to set up a general and highly diastereoselective protocol for the synthesis of 2-alkyl-1,3-diols with 1,2-syn relationship. This ...
PURPOSE:To obtain an azole compound useful as an agricultural and horticultural fungicide, in high yield and purity, by the selective reduction of the ketone group of a specific azole-type alpha,beta-conjugated unsaturated ketone compound using triisobutyl aluminum as the reducing agent. CONSTITUTION...
(1.3 mmol ketone, 83 mmol 2-propanol, 100 mg catalyst under reflux with stirring) aturnover frequencyof 632 h−1was reported. The stereoselectivity is very high;cis:trans>99:1. Of particular interest is the high tolerance of Zr-Beta towards water. With 9% (wt) of water added in the...
Broadly speaking, MPV reduction consists of a hydrogen transfer between alcohol and aldehyde or ketone, yielding a new alcohol and carbonyl compound, as show below in Figure 1. Figure 1. Typical reaction scheme of the Meerwein-Ponndorf-Verley reduction (R1= -H, -alkyl, -allyl, -aryl; R2=...
Biotechnology for Biofuels and Bioproducts (2024) 17:144 Page 6 of 13 Fig. 2 Pyridine pathway of nicotine degradation in Arthrobacter sp. involves key enzymes: nicotine dehydrogenase (NDH), 6-hydroxy-l-nicotine oxidase (6-HLNO), 6-hydroxy-d-nicotine oxidase (6HDNO), ketone ...
conversion. We further demonstrate the applicability of this pathway to acetone, highlighting its broader role in the early stages of the reaction. Introduction Fig. 1: Roles of aldehyde/ketone in methanol conversion over zeolites. The methanol conversion is a well-established example of autocatalysis...
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The process is characterized in that a ketone of the general formula (±)-II, in which A, B and R have the meaning indicated above, is treated with microorganisms, and the resulting 3alpha-hydroxy-prostacyclin intermediate product, which in its configuration corresponds to the natural PGI2, is...
the ketone is reduced non-stereoselectively to give a mixture of equal amounts of the α-hydroxy and β-hydroxy epimers, whereas, in the case of natural prostaglandins E1, E2, F1α and R2α, and of synthetic analogues which are being developed now, it is only the 15α-hydroxy epimer wh...
The present invention provides a process for reducing carbonyl compounds to hydroxy compounds, in particular stereoselectively reducing alpha -aminohaloketone derivatives, under mild conditions in an easy and simple manner, which comprises reacting a carbonyl compound of the general formula (1) with an...