Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD. Gut. 2016;65(7):1202–14. https://doi.org/10.1136/gutjnl-2015-310798. Article PubMed CAS Google Scholar Mouskeftara T, Deda O, Papadopoulos G, Chatzigeorgiou A, Gika H. Lipidomic analysis ...
“Inflammation is a product of the immune system, but it’s not inherently bad,” says functional medicine expert Will Cole, IFMCP, DNM, DC, author ofThe Inflammation Spectrum. “We need healthy balanced inflammation levels in the body. Inflammation helps fight off viruses. Assists in hea...
Therefore, complete deletion of TAK1 or whole-body inhibition of TAK1 activity may also induce serious side effects44. In the present study, Takinib that inhibited the whole-body TAK1 showed a strong basal phenotype in OTUD5f/f-T2DM mice, which may make it very difficult for podocyte OT...
Xu et al. reported that intratracheal instillation of 5 or 10 mg of C60(OH)n in rats resulted in cell damage, oxidative/nitrosative stress, and inflammation, as assessed by bronchoalveolar lavage fluid biomarkers and pathological evaluation of lung tissue after 3 days of exposure [42]. Rours...
Cigarette smoke contains many harmful chemicals, such as tobacco-specific N-nitrosamines (TSNAs), benzene, pesticides, arsenic, cadmium, cyanide, and many many more. These toxins circulate all around the body and cause oxidative damage to the cells of the eye, thus promoting inflammation and affec...
The nuclear receptor peroxisome proliferator-activated receptor β/δ (PPARβ/δ) regulates glucose and lipid metabolism, as well as inflammation. In fact, PPARβ/δ agonists attenuate dyslipidemia and hyperglycemia, improve whole-body insulin sensitivity and prevent HFD-induced obesity [9]. PPARβ/...
To combat the SARS-CoV-2 pandemic, innovative prevention strategies are needed, including reducing ACE2 expression on respiratory cells. This study screened approved drugs in China for their ability to downregulate ACE2. Daphnetin (DAP) was found to sign
(45–55 years of age,n = 20, 50% women) who undertook a 20-week RT program (70% RM, whole body targeted [8 exercises], 3 times per week) experienced 1.1% increase in total LTM23. In the AT group, we found a significant decrease in body weight and BMI and a significant ...
Unexpectedly, our study found that whole-body Marc1 deficiency in mouse is not protective against hepatic triglyceride accumulation, liver inflammation or fibrosis. In attempts to explain the lack of the observed phenotype, we discovered that Marc1 plays only a minor role ...
1. A method for reducing or inhibiting brain inflammation in a neurodegenerative disease or disorder which involves the pathological effects of amyloid beta, comprising administering to a subject in need thereof by active or passive immunotherapy an effective amount of a phage displaying the amino acid...