K HNAST S,VAN DER TUIN S J,VAD DER HOOM J W,et al.Anacetrapib reduces progression of atherosclerosis,mainly by reducing non-HDL-cholesterol,improves lesion stability and adds to the beneficial effects of atorvastatin[J].Eur Heart J,2015,36(1):39-48....
To complicate matters, not all cholesterol contributes to heart and blood vessel problems. One type, called high-density lipoprotein (HDL) cholesterol, or "good cholesterol," actually lowers the risk of these problems. The other type, low-density lipoprotein (LDL) cholesterol, or "bad cholesterol...
induced increase in HDL-cholesterol is dependent on the expression of the cholesteryl ester transfer protein (CETP). To this end, APOE*3-Leiden (E3L) transgenic mice without and with the human CETP transgene, under the control of its natural regulatory flanking regions, were fed a Western- ...
(Fig.1a). HTE dramatically lowered total cholesterol and LDL-c levels and increased the high-density lipoprotein cholesterol (HDL-c) level in the blood, but did not alter serum triglycerides (Fig.1a). The HCHFD increased the levels of serum transaminases, aspartate aminotransferase (AST), and...
Table3shows the changes in serum lipid parameters by addition of lard or lard + flaxseed in Sham and Ovx groups. Ovariectomy significantly increased serum total cholesterol, non-HDL cholesterol, and TG. High-fat diet resulted in increased serum total cholesterol, non-HDL cholesterol, and TG as ...
HDL possesses anti-inflammatory and anti-oxidant properties, but its principal anti-atherogenic function is thought to be due to its ability to mediate reverse cholesterol transport (RCT). While macrophages possess a passive diffusion mechanism for cholesterol removal, the association of apoA-I with ...
. In preclinical and clinical studies, pemafibrate shows greater plasma TG lowering and HDL-cholesterol elevating effects than those of other fibrates on the market14,15. We have reported that pemafibrate induces a series of PPARα target genes involved in TG hydrolysis, fatty acid uptake, fatty ...
obtaining an antibody specific to an adenovirus type 36p, and; assaying the sample using the antibody to test for the presence of the adenovirus type 36p thus testing whether the person has been or is infected with adenovirus type 36p, which causes obesity and reduces cholesterol level in hum...
lipoproteins, which the committee identified as a target for intervention as well as LDL-C. The committee formalized the concept of “non-HDL cholesterol” (non-HDL-C) as a target for therapy in persons with hypertriglyceridemia, perhaps more relevant than LDL-C alone in these individuals. Non...
(LDL) cholesterol or low levels of high density lipoprotein (HDL) cholesterol among other factors. When LDL cholesterol levels are decreased, there typically is a decrease in risk of heart disease. Thus, a desire exists to find ways to reduce LDL cholesterol levels in risk subjects, such as ...