Related to reduced hemoglobin:methemoglobin,cyanosis he·mo·glo·bin (hē′mə-glō′bĭn) n. The protein in the red blood cells of vertebrates that carries oxygen from the lungs to tissues and that consists of four polypeptide subunits, each of which is bound to an iron-containing heme...
The ability to directly measure hemoglobin concentrations is advantageous compared to MRI, which indirectly estimates the oxyhemoglobin saturation of large vessels by measur- ing the (assumed to be deoxyhemoglobin) difference in susceptibility between the outside and inside of the vessel. This works ...
A comparison of the kinetic absorbance difference spectrum for the reduction of methemoglobin with the static difference spectrum of deoxyhemoglobin and methemoglobin in the Soret-region revealed a decreased absorbance of the unliganded subunit of Hb3+ at 430 nm. This fact suggests that Hb3+ is ...
the source of ART activator10,11. The role of heme-ART adducts is further supported by the detection of those adducts by LC-MS in live malaria parasites grown under culture conditions12,13. Non-heme (inorganic) iron, heme and hemoglobin are all implicated as key molecules in...
Formation of deoxyhemoglobin and oxidized form of flavin mononucleotide by the reaction proceeded stoichiometrically in a ratio of unity. These results apparently indicate that the limiting step for the reduction of methemoglobin by the NADPH-flavin reductase system in human erythrocytes is the enzymatic...
Sickle Cell Hemoglobin in the Ferryl State Promotes βCys-93 Oxidation and Mitochondrial Dysfunction in Epithelial Lung Cells (E10). Polymerization of intraerythrocytic deoxyhemoglobin S (HbS) is the primary molecular event that leads to hemolytic anemia in sickle cell disease (SCD). We ... Tigist...
A comparison of the kinetic absorbance difference spectrum for the reduction of methemoglobin with the static difference spectrum of deoxyhemoglobin and methemoglobin in the Soret-region revealed a decreased absorbance of the unliganded subunit of Hb 3+ at 430 nm. This fact suggests that Hb 3+ ...
Formation of deoxyhemoglobin and oxidized form of flavin mononucleotide by the reaction proceeded stoichiometrically in a ratio of unity. These results apparently indicate that the limiting step for the reduction of methemoglobin by the NADPH-flavin reductase system in human erythrocytes is the enzymatic...
To assess cerebral and muscular oxygenation, throughout exercise, near-infrared spectroscopy allowed investigation of changes in oxyhemoglobin (O2Hb), deoxyhemoglobin (HHb), and total hemoglobin (THb) in the prefrontal cortex and in the vastus lateralis muscle. Results: ESRD patients demonstrated lower...
The roles of changes in deoxyhemoglobin concentration and regional cerebral blood volume in the fMRI BOLD signal. Neuroimage 2003, 19, 1521–1531. 4. Gratton, E.; Toronov, V.; Wolf, U.; Wolf, M.; Webb, A. Measurement of brain activity by near-infrared light. J. Biomed. Opt. 2005...