Hemolysis is a cardinal feature of hemolytic uremic syndrome (HUS) and during hemolysis excess arginase 1 is released from red blood cells. Increased arginase activity leads to reduced L-arginine, as it is converted to urea and L-ornithine, and thereby r
Development of R-GenGAR-DA1.2, which showed a negative red fluorescence response to DA.aSchematic illustration of a mutation site. Glutamine (Gln) was introduced into the N-terminal side of a linker in DA1.1.bRepresentative images of HeLa cells expressing DA1.2 treated with 10 µM DA, foll...
Blood samples were obtained on the day of hospitalization or within two days for patients in both HUS cohorts. Samples were taken before the start of peritoneal dialysis. Remission samples were available for 12/24 patients in the first (Lund) HUS cohort and collected at a median of three week...
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