However, the necessity to grow the parasite either in macaques or in vitro using macaque blood restricted research to laboratories with access to these resources. The recent adaptation of P. knowlesi to grow and proliferate in vitro in human red blood cells (RBCs) is therefore a substantial ...
Most attention has been focused on the role of endothelial-derived NO in basal blood flow regulation by relaxing vascular smooth muscle; however, it is now known that NO derived from red blood cells (RBCs) plays a fundamental role in vascular homeostasis by enhancing oxygen (O2) release at ...
Structure and Adaptations of Red Blood Cells to their Function Biconcave ShapeOne of the most important adaptations of the red cells is their general shape. Generally, erythrocytes are shaped like a doughnut, without a hole in the middle. This is an important adaptation that allows the cell to...
Red Blood Cells 血红细胞 Red Blood Cells 血红细胞 Erythrocytes, or red blood cells, are the primary carriers of oxygen to the cells and tissues of the body. The biconcave shape of the erythrocyte is an adaptation for maximizing the surface area across which oxygen is exchanged for carbon ...
Red blood cells (RBCs) have been shown to affect immune function and can induce inflammatory responses after transfusion. The transfusion of washed RBCs can significantly reduce adverse effects, however, the soluble factors that may mediate these effects
The latter refers to a reduction of the red blood cell volume fraction or hematocrit, with decreasing vessel diameter18,22–24. The influence of a stenosis on the Fahraeus-Lindqvist and Fahraeus effects is unknown, and is one objective of this study. Also unknown is the local hemodynamic ...
Hemolysis is a cardinal feature of hemolytic uremic syndrome (HUS) and during hemolysis excess arginase 1 is released from red blood cells. Increased arginase activity leads to reduced L-arginine, as it is converted to urea and L-ornithine, and thereby r
Mature red blood cells (RBCs) ofcamelsalso do not contain nucleus. The absence of a nucleus is an adaptation of the red blood cell for its role. It allows the red blood cell to contain more hemoglobin and, therefore, carry more oxygen molecules. ...
Treosulfan is a prodrug applied in the treatment of ovarian cancer and conditioning prior to stem cell transplantation. So far, the bioanalysis of treosulfan in either whole blood or red blood cells (RBC) has not been carried out. In this work, the RBC/plasma partition coefficient (Ke/p) ...
(1982), Mechanisms of dynamic flow adaptation of mammalian erythrocytes,Naturwissenschaften 69, 294–296. Article PubMed CAS Google Scholar Secomb, T. W. and Skalak, R. (1982), A two-dimensional model for capillary flow of an asymmetric cell,Microvasc. Res. 24, 194–203. Article PubMed ...