Novel approaches are desperately needed for women with this disease.CASES:Two patients with advanced or recurrent primary mucinous ovarian cancer were treated with secondary cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC). No additional chemotherapy was administered post...
Survival benefits with diverse chemotherapy regimens for ovarian cancer:meta-analysis of multiple treatments[J]. J Natl Cancer Inst, 2006, 98(22):1655-1663. doi: 10.1093/jnci/djj443 [17] Cheng X, Jiang R, Li ZT, et al. The role of secondary cytoreductive surgery for recurrent mucinous ...
Intermediate magnification micrograph of a low malignant potential (LMP) mucinous ovarian tumour. H&E stain. The micrograph shows: Simple mucinous epithelium (right) and mucinous epithelium that pseudo-stratifies (left - diagnostic of a LMP tumour). Epithelium in a frond-like architecture is seen ...
Age Ascites Bowel resection CA125 >251 U ml–1 ECOG 2–3 Extent of recurrence Grade 2 Grade 3 Mucinous Endometrioid Clear cell Others PFI >23.1 months RD1 >0 cm RD2 0–1cm RD2 >1cm Size of recurrence FIGO stage III/IV Year of the data 1.00 0.90 0.80 0.70 0.60 0.50 0.40 0.30 ...
Mucinous Carcinoma Clear Cell Carcinoma Serous Carcinoma Normal Adenocarcinoma Normal Adenocarcinoma Normal Papillary Carcinoma Follicular Carcinoma Normal Adenocarcinoma Ductal Endometrium Endometrial Carcinoma Leiomyosarcoma MSANTD3 strong immunostaining (No. cases) 14 0 19 2 4 1 1 0 14...
with standard chemotherapy, as well as in the phase 3 FIRST (NCT03602859) trial of dostarlimab and niraparib (Zejula) plus platinum-based chemotherapy versus standard platinum-based therapy alone as a frontline therapy for patients with stage III/IV non-mucinous epithelial ovarian cancer...
Dostarlimab is being investigated in registrational enabling studies as monotherapy and as part of combination regimens, including in patients with primary advanced or recurrent endometrial cancer, patients with Stage III o...
et al. Whole-exome sequencing uncovers frequent GNAS mutations in intraductal papillary mucinous neoplasms of the pancreas. Sci Rep 1, 161 (2011). 26. Shimojima, K. et al. TULIP1 (RALGAPA1) haploinsufficiency with brain development delay. Genomics 94, 414–422 (2009). 27. Kuboki, Y. ...
Y. Multidriver mutation analysis in pulmonary mucinous adenocarcinoma in Taiwan: identification of a rare CD74-NRG1 translocation case. Med. Oncol. 31, 34 (2014). 22. Nakaoku, T. et al. Druggable oncogene fusions in invasive mucinous lung adenocarcinoma. Clin. Cancer Res. 20, 3087–3093 (...
ab is being investigated in other registrational-enabling studies, as monotherapy and as part of combination regimens for women with recurrent or primary advanced endometrial cancer stage III or IV non-mucinous epithelial ovarian cancer for patients with advanced solid tumours or metastatic cancer....