MoustakasA,PardaliK,GaalA ,et al.Mechanisms of TGF-β signaling in regulation of cell growth and differentiation[J]. ImmunolLett, 2002;82:85–91. Wang J, Guo L, Shen D, et al. The Role of c-SKI in Regulation of TGF beta-Induced Human Cardiac Fibroblast Proliferation and ECM Protein Ex...
通过观察Endostar联合放疗对肺腺癌A549细胞增值及TGF-β1、HIF-1α表达的影响,初步探讨重组血管内皮抑素的放疗增敏机制。方法:将培养至对数生长期的A549细胞分为对照组、单纯放疗组、恩度组、联合组,检测各组A549细胞增殖率及TGF-β1、HIF-1α蛋白和mRNA表达情况。结果:1) 除对照组外,各组细胞的增殖随时间的改变...
TGF‑ beta 1 shares 99‑100% aa sequence identity with human, rat, equine, porcine, canine and bovine TGF‑ beta 1. It demonstrates cross‑species activity (1). TGF‑ beta 1 signaling begins with high‑affinity binding to a type II ser/thr kinase receptor termed TGF‑ beta ...
We further observed, both in vitro and in vivo, an increase in pSMAD2/3, an important mediator of TGF-β signaling, after treatment with PSG1 [47]. The results presented here support the potential benefits of PSG1 in treating aGVHD. We found that after administration of PSG1 in an ...
生物活性:Immobilized Recombinant Human TGF-beta 1 Monomer protein (rp176238) at 1.0 μg/mL can bind Recombinant TGF beta 1 Antibody (Ab130853) with the EC50 of 5 ng/mL. 内毒素水平:<1 EU/μg 货号(SKU)包装规格是否现货价格数量 rp176238-10μg(试用装) ...
TGF beta 1 recombinant protein Cited in 182 papers. Free of endotoxin and animal components. Authentic glycosylation, maturation, and folding lead to greater stability and activity than CHO and E. coli systems.
The EGFR subfamily of receptor tyrosine kinases comprises four members: EGFR , ErbB2,ErbB3, and ErbB4. All family members are type I transmembrane glycoproteins.EGFR binds a subset of the EGF family ligands, including EGF, amphiregulin, TGF-alpha, betacellulin, epiregulin, and HB-EGF. Ligand...
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (TAB1) is a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. TAB1 interacts and thus activates...
regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. smad2 interacts with the tgf-beta receptors through its interaction with the smad anchor for receptor activation into the nucleus is a central event in tgf beta signaling. phosphorylation of threonine 8 ...
TGFB, also named as LAP and TGFB1, is a multifunctional peptide that controls proliferation, and cell differentiation. TGF acts synergistically with TGFA in inducing transformation process. It also acts as a negative autocrine growth factor. Dysregulation of TGFB activation and signaling may result in...