3.1Recombinant chimeric vaccines Recombinant chimeric vaccine is the first strategy used in the development of candidate CSF vaccines. The live vaccine is generally an excellent inducer of long-term immunity by eliciting both humoral and cellular immune responses against the inserted antigen. Some live ...
Development of cold-adapted recombinant live, attenuated influenza A vaccines in the USA and USSR. Antiviral Res 1981;1:339-65.Kendal AP, Maassab HF, Alexandrova GI, Ghendon YZ. 1981. Devel- opment of cold-adapted recombinant live, attenuated influenza A vac- cines in the USA and USSR. ...
MedImmune Vaccines (formerly Aviron) was developing a genetically-engineered live herpes simplex virus type 2 (HSV-2) vaccine for use in uninfected children and
ANDREASEN, J.R.: "STUDIES OF INFECTIOUS LARYNGOTRACHEITIS VACCINES: IMMUNITY IN BROILERS" AVIAN DISEASES, vol. 33, no. 3, 1989, pages 516-523, XP001070029 BACON, L.D.: "EFFICACY OF MAREK'S DISEASE VACCINES IN MHC HETEROZYGOUS CHICKENS: MHC CONGENIC X INBRED LINE F1 MATINGS" JOURNAL ...
9.1Live and Non-live Vaccines The original scientific strategy behind vaccinology has historically been to “isolate, inactivate, and inject,” first invoked by Louis Pasteur. The recombinant DNA and nanotechnology did much enlarge the repertoire on vaccines, which is today based on three adjusted pr...
ofinsufficientmagnitudetodeliverclinicalbenefit.Liverecombinantviralvaccineshavebeenusedinthedevelopmentof cancerimmunotherapyapproachesforthepast10years.Thoughsuchvectorsareself-adjuvantedandoffertheabilitytoexpress multipletumour-associatedantigens(TAAs)alongwithanarrayofimmuneco-factors,arguably,theyhaveyettodemonstrate ...
Vaccines and therapies are urgently needed to address public health needs stemming from emerging pathogens and biological threat agents such as the filoviruses Ebola virus (EBOV) and Marburg virus (MARV). Here, we developed replication-competent vaccines against EBOV and MARV based on attenuated r...
6,7 Vaccination has the potential to provide long-term protection against herpes zoster, but live attenuated vaccines are contraindicated in immunocompromised individuals because of the risk of varicella resulting from spread of the vaccine strain.8,9 An adjuvanted recombinant zoster vaccine, consisting ...
While they are efficacious, use of these live virus vaccines carries considerable risks of vaccine-associated viral shedding and recombination. Here, we present an alternative vaccination strategy against AdV-7 using the virus-like particle platform (AdVLP-7). We describe the production of stable ...
Recombinant vaccinia viruses as new live vaccines. Smith,G. L.,Mackett,M.,Moss,B. Biotechnology and Genetic Engineering Reviews . 1984Smith, G. L., Mackett, M. & Moss, B. 1984 Recombinant vaccinia viruses as new live vaccines. Biotechnology and Genetic Engineering Reviews 2 , 383–407....