Recombinant Human Serum Albumin as an Excipient for Preventing Protein Aggregates and ParticlesHuman serum albumin (Alb) has historically been used extensively in the formulation of a wide range of proteins. The potential impurities due to sourcing of the material from serum and the batch-to-batch...
Recombumin® recombinant human albumin is a multifunctional excipient, and its stabilization properties have been validated across multiple products. For complex biopharmaceuticals, such as advanced therapies, Recombumin® addresses a growing need for chemically-defined, consistent, animal- and human-orig...
Recombumin® recombinant human albumin is a multifunctional excipient, and its stabilization properties have been validated across multiple products. For complex biopharmaceuticals, such as advanced therapies, Recombumin® addresses a growing need for chemically-defined, consistent, animal- and human-orig...
Due to its human origin native HSA demonstrates a low toxicity and immunogenicity, but it bears the risk of infection, e.g. with human immunodeficiency virus. Recombinant HSA (rHSA) can be manufactured in a biotechnological process and has been in use as a plasma expander and ...
The objective was to evaluate the impact of pH and NaCl content on aggregation, particle formation, and solubility of a hydrophobic recombinant human cytokine in formulations with human serum albumin (HSA) as stabilizing excipient. While cytokine-HSA formulations were stable at physiological pH, a tr...
Hyature® is a pharmaceutical grade sodium hyaluronate which can be used as an API or excipient for drugs and medical devices in ophthalmic preparations, intra-articular injections, anti-adhesive preparations, topical preparations for wound healing and soft tissue filler, etc. Hyature® sodium hya...
The development of parenteral solution dosage forms of interferon [alpha] 2 (rhIFN-[alpha]2) without human albumin may significantly diminish the problem of forming highly immunogenic rhIFN-[alpha]2b aggregates and the potential risk of blood-transmitted diseases caused by infectious viruses and oft...
Recombumin® recombinant human albumin is a multifunctional excipient, and its stabilization properties have been validated across multiple products. For complex biopharmaceuticals, such as advanced therapies, Recombumin® addresses a growing need for chemically-defined, consistent, animal- and human-orig...
23. A pharmaceutical composition comprising the RPP of claim 1 and a pharmaceutically acceptable excipient. 24. A method of treating a subject in need thereof, the method comprising administering to the subject an effective amount of the RPPs of claim 1. 25. The method of claim 24, wherein...
Pharmaceutical compositions may be administered in admixture with a suitable carrier, diluent, or excipient such as sterile water, physiological saline, glucose, or the like. The compositions can contain auxiliary substances such as wetting or emulsifying agents, pH buffering agents, adjuvants, gelling...