重组人神经生长因子之赛奈吉明及新药汇总根据全球新药竞争情报库-Synapse搜索可知,共有6家公司(表1)已生产出重组人神经生长因子(recombinant human nerve growth factor,rhNGF)并用于临床试验,除Dompe Farmaceutici SpA公司研发的赛奈吉明(别名:OXERVATE)为原研药,并已批准上市,其他5种药品均处于临床试验阶段。图1 赛...
Allen SJ,Robertson AG,Tyler SJ,et al.Recombinant human nerve growth factor for clinical trials:protein expression,purification,stability and characterisation of binding to infusion pumps. Journal of Biochemical and Biophysical Methods . 2001Allen SJ, Robertson AG, Tyler SJ, et al. Recombinant human ...
In this article, we describe a clinically translatable topical, neuroprotective treatment (recombinant human nerve growth factor, rh-NGF) predominantly targeting secondary degeneration in a pONT rat model. Topical application of rh-NGF twice daily for 3 weeks significantly improves RGC survival as shown...
In this study we evaluated the effect of recombinant human nerve growth factor (rhNGF) on cisplatin (CDDP)-induced sensory neuronopathy in an experimental paradigm in the rat. Young adult female Wistar rats were treated with CDDP (2 mg/kg ip twice weekly for nine times) alone or in ...
Combination of Recombinant Human Nerve Growth Factor with Sesamin: a Novel Strategy to Alleviate Neuropathic Corneal Pain Purpose : Neuropathic corneal pain (NCP), is difficult to treat and no treatments are currently available. NCP is initiated by corneal nerve injury, and mediated by ...
Aim To investigate the effect of recombinant human nerve growth factor( rhNGF) on refractory wound model in diabetic rats. Methods Male SD rats were injected intraperitoneally with streptozotocin( 60 mg·kg~(-1)) to prepare a diabetes model; scald wound was prepared on the back of rats to ...
This strategy enables the expressed rhNGF not only avoid the problems associated with inclusion body denaturation and refolding but also maintain its biological activity. 展开 关键词: Nerve growth factor Fusion protein Purification Biological activity ...
NGF-beta, human recombinant 供应商 Biovision 产品货号 4303R-20 产品报价 ￥已停产 产品说明书 点击查看 购买方式 银行转账、电汇、支票、现金,在线支付宝及网银支付,或直接与我们电话联系400-6800-868. 产品新闻 背景资料 Nerve growth factor-β (NGF-β) is a potent neurotrophic factor that supports the...
NGF-beta, human recombinant 供应商 Biovision 产品货号 4303R-1000 产品报价 ￥已停产 产品说明书 点击查看 购买方式 银行转账、电汇、支票、现金,在线支付宝及网银支付,或直接与我们电话联系400-6800-868. 产品新闻 背景资料 Nerve growth factor-β (NGF-β) is a potent neurotrophic factor that supports th...
The gene for human nerve growth factor (NGF) has been cloned into a mammalian cell line and large quantities of recombinant human NGF (rhNGF) can now be produced for clinical use, but little is known about the fate of rhNGF following delivery to the brain. In this study, we implanted ...