Complications of Recombinant Human BMP-2 for Treating Complex Tibial Plateau Fractures: A Preliminary Report. Clin Orthop Relat Res. 2009;467(12):3257-62.Boraiah Sreevathsa,Paul Omesh,Hawkes David,Wickham Matthew,Lorich Dean G.Complications of recombinant human BMP-2 for treating complex tibial ...
Genentech produced thefirst human protein,somatostatin, inE. colicells in 1977. The next year the company cloned the human insulin gene and in 1982, the firstrecombinant DNAdrug to be marketed, “Humulin,” was licensed to Eli Lilly and Company.Humangrowth hormonecloned by Genentech in...
When used, 0.1 % acetic acid was utilized to dissolve the BMP2 powder. Control rhBMP2 was purchased from R & D systems (Minneapolis, USA) derived from CHO cells. Two-dimensional migration assay MC3T3-E1 pre-osteoblast cell line was used for this study. No human or animal samples were ...
Efficacy of Recombinant Human BMP2 and PDGF-BB in Orofacial Bone Regeneration: A Systematic Review and Meta-analysisOutcomes researchTranslational researchWith the rapid development of tissue engineering therapies, there is a growing interest in the application of recombinant human growth factors (rhGFs)...
Bone morphogenetic protein (BMP) has been increasingly used in the US for a wide range of spinal fusion procedures because of the potential surgical and postsurgical benefits it provides and the perceived reduction in complications related to iliac crest bone graft harvesting. Recombinant human BMP-2...
Currently, recombinant human BMP-2 (rhBMP-2) coupled with an absorbable collagen sponge (ACS) manufactured from bovine Achilles tendon Type 1 collagen is the only FDA approved device for orthopedic and craniofacial indications. Although the rhBMP-2/ACS construct has demonstrated clinical efficacy for...
We sought to determine our fusion rate when combining allograft with recombinant human bone morphogenetic protein-2 (rh-BMP2) and rigid screw fixation. Methods We reviewed our experience using allograft, bone morphogenetic protein (rh-BMP2) and screw fixation of C1-C2 in 52 patients and examined...
To date, more than twenty human BMPs have been identified. Of these, BMP-2 and BMP-7 (also known as osteogenic protein 1 or OP-1) are the only BMPs used clinically. Recombinant forms of both proteins are currently being implanted surgically to induce spinal fusion and to treat long ...
PurposeThis study aimed to identify the main indications for the use of recombinant human bone morphogenetic protein-2 (rhBMP-2) for bone repair and maintenance in the maxilla and mandible through a review of clinical trials evaluating the viability of using rhBMP-2 to delay the installation of ...
Compared to recombinant human BMP-2 (rhBMP-2), which is approved for clinical use, regional gene therapy may have unique benefits related to the addition of MSCs and the sustained release of BMP-2. However, the cellular and transcriptional mechanisms regulating the response to these two ...