The purpose of this study was to establish the eventual presence of progesterone receptor (PGR) and oestrogen receptor (EGR) in human middle-ear cholesteatoma (MECh) tissues and to compare their expression between male and female patients. An immunohistochemical technique was employed for detection of...
These pharmacological effects of neuroleptics at receptors in brain and elsewhere in the body are likely responsible for therap... E Richelson - 《Annals of the New York Academy of Sciences》 被引量: 185发表: 2010年 Visualisation of serotonin-1A (5-HT) receptors in the central nervous system...
Steroids labeled with tritium may be observed in body fluids tissues and various cell components by the response of the reacting cell not by the steroid itself. The steroid receptors discovered so far are oligomeric proteins whose composition is dependent upon ionic strength. Progesterone receptors are...
A significant proportion of both GABA-BR1 and GABA-A receptor immunolabeling is extrasynaptic, but GABA-A receptor subunits also aggregate in the main body of putative GABAergic symmetric synapses established by striatal- and pallidal-like terminals. GABA-BR1 immunoreactivity is expressed presynaptic...
In adults, α1 GlyRs were found at all relay stations of the auditory pathway except for the medial geniculate body and the auditory cortex. In most brainstem nuclei, labeling was characterized by dense clusters of heavily immunoreactive puncta outlining the somata and proximal dendrites, indicative...
Many overweight or obese people struggle to sustain the behavioural changes necessary to achieve and maintain weight loss. In rodents, obesogenic diet can disrupt goal-directed control of responding for food reinforcers, which may indicate that diet can
hydroxycarboxylic acid receptor 2 (HCA2)— which is also activated by nicotinic acid — in particular is of pharmacological interest as it mediates some anti-dyslipidaemic effects as well as anti-inflammatory effects, which can be used to reduce the progression of atherosclerosis and potentially ...
1. The receptive fields of 48 specific cold units, located in the hairy and glaborous skin of fore- and hindlimbs of , were mapped and scale drawings made. Forty-five percent had single spotlike receptive fields of 1-2 mm diameter or were up to 2 mm wide and 3-5 mm long, and fo...
Sex hormones strongly influence body fat distribution and adipocyte differentiation. Estrogens and testosterone differentially affect adipocyte physiology,... L Fernando,G Guillermo - 《Biomed Research International》 被引量: 154发表: 2014年 Estrogen signaling in the cardiovascular system Estrogen exerts comp...
Neuropeptide Y (NPY) administration into the basolateral amygdala (BLA) decreases anxiety-like behavior, mediated in part through the Y1 receptor (Y1R) isoform. Activation of Y1Rs results in G-protein-mediated reduction of cAMP levels, which results in r