There has emerged an enormous body of literature describing the locations of ET receptors within various cell, tissue, and organ systems as well as the myriad of effects produced following their activation. In large part, the great interest in ET receptor biology is generated in response to the...
A growing number of G protein-coupled receptors (GPCRs) are being identified as sensors for ligands that are energy substrates or metabolic intermediates, and their central role in the coordination of metabolic processes is increasingly being recognized.
Androgen receptor (AR) belongs to the steroid hormone receptor group of ligand-activated transcription factors in the nuclear receptor superfamily. AR mediates the action of physiological and exogenous androgens to regulate the expression of a network of genes in target tissues that are essential for ...
There is a substantial interest in the development of NK1 substance P antagonists as potential treatments for various neuropsychiatric and somatic disorders. The aim of this study was to determine whether [18F]SPA-RQ can be utilized as a tool for studying the whole body distribution and function...
The BBSome in POMC and AgRP Neurons Is Necessary for Body Weight Regulation and Sorting of Metabolic Receptorsdoi:10.2337/DB18-1088Deng-Fu GuoZhihong LinYuanming WuCharles SearbyDaniel R. ThedensGeorge B. RichersonYuriy M. UsachevJustin L. Grobe...
One important function of the gut microbiome is bile acid (BA) metabolism. In humans, primary BAs are synthesized from cholesterol in the liver, and are then conjugated with taurine (T) or glycine. In mice, T-conjugated BAs are abundant. In the intestine, bacteria can perform deconjugation,...
In recent years, a large number of studies revealed that dysbiosis or the localized intestinal infection may trigger systemic immune response, resulting in exacerbated inflammatory response in AD brain [26]. Dysbiosis refers to microbial imbalance on or inside the body. Intestinal microbiota can bidire...
An interesting molecule in this aspect is pituitary adenylate cyclase activating peptide (PACAP), which exists in the body as 38- and 27- amino acid peptides [4, 5]. These peptides partly share receptors with their family member vasoactive intestinal peptide (VIP) [6]. In migraineurs, ...
A growing body of evidence suggests that serotonin plays an important role in the early development of both neural and non-neural tissues from vertebrate a... SR Hansson,E Mezey,BJ Hoffman - 《Neuroscience》 被引量: 166发表: 1999年 Expression of the tight junction protein ZO-1 in the olfac...
83which requires the recognition of PRRs in the body. NLRs are intracellular PRRs, composed of three domains:84,85one is the central nucleotide-binding domain (NBD), also known as the NACHT domain (synthesized by the abbreviations of the following four kinds of NLR members: NAIP, CIITA, ...