Beyond CAR-T, our analysis applies to several additional types of modular treatment technologies that rely instead on receptor-mediated endocytosis (RME) delivering a toxin via a targeted receptor to enter the cell31,32. These RME-based technologies include, e.g., conjugated antibodies and toxin ...
As such, it is reasonable to make the assumption that nanoparticles that entered via biomarkers expressed cells via receptor-mediated targeted endocytosis into the lysosomes. Overall, successful detection of a biomarker protein was achieved with the use of NPs, rather than conventional dyes used for ...
This review outlines the mechanisms governing the major modes of receptor-mediated endocytosis used in drug delivery and highlights recent approaches using these as targets for in vivo drug delivery of nanoparticles. The review also discusses some of the inherent complexity associated with the simple ...
Figure 4. PAC regulates endosomal pH, Cl− concentration, and transferrin-receptor-mediated endocytosis (A) A simple model focusing on Cl− in endosomal pH regulation: PAC functions as a pH sensor in endosomes and prevents hyper-acidification by releasing Cl− from the lumen. Loss and gain...
Abstract: Sortilin (SORT1) receptor-mediated endocytosis functions were exploited for this new approach for effective and safe treatments of gynecological cancers. Here, high expression of SORT1 was found in >75% of the clinically annotated ovarian and endometrial tumors analyzed by immunohistochemistry...
Why do cells bring in cholesterol LDL during receptor-mediated endocytosis? How does the structure of cholesterol relate to its functions in cell membranes? What is the function of the cholesterol molecules in a cell membrane? How is cholesterol transported into...
Viral infection is an intricate process that requires the concerted action of both viral and host cell components. Entry of viruses into cells is initiated by interactions between viral proteins and their cell surface receptors. Despite recent progress,
Increased levels of βCTF have been observed in patients with AD, and recent research has revealed an Aβ-independent mechanism causing dysregulation of endocytosis (Kim et al., 2015, Pimplikar et al., 2010). Consistent with this evidence, genetic reduction in BACE1 activity in a mouse model...
3F). The correlated changes in ZIP14 and zinc in endosomal fractions suggest that ZIP14 is internalized by endocytosis. ZIP14-mediated Zinc Transport Regulates Endosomal IR Activity Upon activation the IR is internalized through either clathrin or caveolin-mediated endocytosis (28, 29). In Fig. 3...
This review outlines the mechanisms governing the major modes of receptor-mediated endocytosis used in drug delivery and highlights recent approaches using these as targets for in vivo drug delivery of nanoparticles. The review also discusses some of the inherent complexity associated with the simple ...