OSN removal in the adult does not disrupt the animal-to-animal variability of patchy LNs32. To the best of our knowledge, a single locus (e.g., environmental experience or heritable trait) that would support animal-to-animal variation in patchy LNs has ...
Type 1 narcolepsy is strongly (98%) associated with human leukocyte antigen (HLA) class II DQA1*01:02/DQB1*06:02 (DQ0602) and highly associated with T cell receptor (TCR) alpha locus polymorphism as well as other immune regulatory loci. ... G Luo,S Yogeshwar,L Lin,... - 《Scientif...
Differential neurotransmitter and receptor expression may underpin the selective vulnerability of several neuronal populations, from the dopaminergic substantia nigra to the adrenergic locus coeruleus and serotonergic raphe nuclei, and their cortical projections60. Furthermore, PD neurodegeneration may alter both...
Analysis of the chromatin structure of the locus using the enzyme DNase I, a tool commonly used to reveal regulatory regions in genetic loci, showed that the GPR40 region in β-cells is preferentially accessible to DNase I digestion. Functional characterization of the GPR40 promoter p...
aberrantdisulfide bridgebetween two receptor monomers.94Up to 15% ofmultiple myelomasharbor an intergenic 4;14 translocation between theFGFR3gene and theimmunoglobulin heavy chainlocus, which places FGFR3 expression under the highly active heavy chain promoter.95Approximately 10% of diffuse-type gastric...
This locus, D. sechellia Ir75a, bears a premature termination codon (PTC) that appears to be fixed in the population. However, D. sechellia Ir75a encodes a functional receptor, owing to efficient translational read-through of the PTC. Read-through is detected only in neurons and is ...
In kappa-knockout mice with the wildtype lambda locus (kappa -/- lambda +/+), the majority of serum light chains are lambda 1. In contrast, kappa-knockout mice with the SJL lambda locus (kappa -/- lambda s/s) show a pronounced expression of lambda 2 and lambda 3, with only some...
Type 1 interferon-producing cells IRSp53: Insulin receptor tyrosine kinase substrate p53 ISC: Intestinal stem cells ITD: Internal tandem duplications ITIM: Immunoreceptor tyrosine-based inhibitory motifs JAK: Janus kinase JDP2: Jun dimerization protein 2 JM: Juxtamembrane JM-B: JM-binding...
Alternative processing of α-thyroid hormone receptor (TRα, NR1A1) mRNAs gives rise to two functionally antagonistic nuclear receptors: TRα1, the α-type receptor, and TRα2, a non-hormone binding variant that is found only in mammals. TRα2 shares an
To define the contribution of this locus to DS phenotypes, we used genome editing to correct its copy number in a mouse model of DS, which normalized antiviral responses, prevented heart malformations, ameliorated developmental delays, improved cognition and attenuated craniofacial anomalies. Triplication...