Delivery and detection of nucleotide analogues Labeling schemes and respective readouts for revealing stem cell proliferative behaviors and fates Labeling schemes and respective readouts for revealing key parameters of cell cycle kinetics Caveats to consider when applying labeling with modified nucleotides The...
The accelerated development of the NADs field has relied on innovations and breakthroughs in foundational technologies, such as chemical synthesis, site-specific modifications, and delivery techniques. These advancements are crucial to ensure the safety, effectiveness, targeting, and applicability of NADs.1...
Phylogenomics is the intersection of the fields of phylogenetics and genomics, aiming to use genome-scale molecular data to resolve the phylogenetic relationships among organisms. In this review, we briefly introduced five methods of data
Phylogenomics is the intersection of the fields of phylogenetics and genomics, aiming to use genome-scale molecular data to resolve the phylogenetic relationships among organisms. In this review, we briefly introduced five methods of data
Unlike the phosphodiester backbone of nucleic acids, a PNA has an achiral backbone of N-(2-aminoethyl)glycine, which connects to the nucleotide bases. This unique achiral structure enables PNAs to be easily synthesized without considering stereoselectivity. The synthesis of PNA oligomers can be ...
While the recognition of pathogen-associated molecular patterns that activate IL-1β is predominantly regulated by the nucleotide-binding oligomerization domain-like receptor (NLR) family. Among them, NLRP3 inflammasome is involved in the innate immune responses in periodontal disease. Subgingival biofilms...
Single nucleotide variants spatial-CITE-seq: Spatial co-indexing of transcriptomes and epitopes SARS-CoV2: Severe acute respiratory syndrome coronavirus 2 SPOTS: Spatial protein and transcriptome sequencing ST: Spatial transcriptomics STARmap: Spatially-resolved transcript amplicon readout mapping St...
RNA structure serves as important genetic information for RNA besides the nucleotide sequence that carries the coding information. Folding endows RNA molecules with catalytic, scaffolding, and perceptive functions. In 1965, Robert Holley and his collaborators published the nucleotide sequence of yeast alani...
Target specific and long-acting delivery of protein, peptide, and nucleotide therapeutics using hyaluronic acid derivatives Journal of Controlled Release, 141 (2010), pp. 2-12 View PDFView articleGoogle Scholar Oliveira et al., 2018 I. Oliveira, A.L. Carvalho, H. Radhouani, C. Gonçalves,...
ESTs are short cDNA sequences (200–800 nucleotide bases in length) that are generated by single-pass 5′or 3′ end sequencing of clones randomly selected from cDNA libraries. Obtaining expressed sequence tags (ESTs) by partial sequencing of cDNA libraries is an effective means of discovering ne...