The Alzheimer Prevention Initiative [17] has planned a clinical trial in a large population of presenilin 1 E280A mutation-carriers in Colombia, whose natural history and transition from asymptomatic through early symptoms and cognitive deficits to overt dementia has been precisely mapped in a land...
While countless therapeutic techniques have been attempted for decades with limited success, alternative strategies aim to transform inhibitory gliotic tissue into an environment conducive to neuronal regeneration and axonal growth through genetic conversion of astrocytes into neurons. This concept gained ...
These developments are complemented by the move to identify pre-dementia AD and improve trial design. Together they provide hope for the future.Abbreviations Aβ: amyloid β protein AD: Alzheimer 's disease APP: amyloid β protein precursor GSK: glycogen synthase kinase HDAC: histone ...
Many studies on chronic liver illnesses have made progress, but exosomes continue to present significant obstacles. The majority of present research on exosome-based therapeutics is focused on cell and animal models, with clinical trials yet to be completed. Exosomes and microvesicles in human fluids ...
Alzheimer’s disease (AD) stands as the predominant form of dementia, presenting significant and escalating global challenges. Its etiology is intricate and diverse, stemming from a combination of factors such as aging, genetics, and environment. Our cur
according to the results of a University of Nebraska-Lincoln demonstration project. The pilot study of 16 adults aged 75 or more years and living alone in an independent living community used an Amazon Echo device for eight weeks. The goal of the research was to understand the influence of pe...
2Dementia Research group, School of Life Sciences, University of Sussex, Falmer, E Sussex BN1 9QG, UK. 3Chemistry Department, Science College, Mustansiriyah University, Baghdad, Iraq. 4Aix-Marseille University, CNRS, INP, Inst Neurophysiopathol, Fac Pharm, Marseille, France. 5University of ...
But enhanced recollection can also occur in dementia patients, for whom the transformative impact of music therapy sometimes opens a floodgate of memories – from cherished childhood experiences and the aromas and tastes of a mother’s kitchen, to lazy summer afternoons spent with family or the atm...
Dunnett SB (1990) Neural Transplantation in Animal Models of Dementia. Eur J Neurosci 2: 567–587 PubMedGoogle Scholar Dunnett SB, Low WC, Iversen SD, Stenevi U, Björklund A (1982) Septal transplants restore maze learning in rats with fornix-fimbria lesions. Brain Res 251: 335–348 ...
[92]. Exosomal RNA NEAT1 has been proposed as another potential biomarker for IBD pathogenesis [93]. Identifying precise and sensitive biomarkers for IBD could significantly enhance diagnosis, treatment, and prognosis, and pave the way for innovative medicines. Therefore, continued research into these...