It provides information on the pathogenesis of HIV and AIDS, its detection and diagnosis and its treatments. It also recommends medicines for AIDS that are approved by Food & Druf Association (FDA) such as Tipranavir, Fosamprenavir, Darunavir, Atazanavir, Enfuvirtide, Raltegravir, Emtricitabine, ...
Breakthrough advances in the chemotherapy of influenza have been achieved in recent years and the approval of zanamivir (RelenzaTM, Biotech Holdings) by the United States FDA in July 1999 for the treatment of type A and type B influenza marked the first new influenza treatments since the approva...
Here, we discuss the insights gained so far relevant to the development of small-molecule CCR5 inhibitors for the treatment of HIV, and highlight small-molecule CCR5 inhibitors that are currently under preclinical and clinical trials. 关键词: HIV, Entry, Co-receptor, CCR5, Small-molecule ...
Treatment of CD20-directed chimeric antigen receptor-modified T cells in patients with relapsed or refractory B-cell non-Hodgkin lymphoma: an early phase IIa trial report. Signal. Transduct. Target. Ther. 1, 16002 (2016). PubMed PubMed Central Google Scholar Fry, T. J. et al. CD22-...
co-infections such as HIV/Leishmaniaspp., the small therapeutic arsenal (pentavalent antimonials, amphotericin B and formulations, and miltefosine), and the low investment for the discovery/development of new drugs force researchers and world health agencies to seek new strategies to combat and contro...
Targeting such undruggable targets has been considered also a great opportunity for treatment of human diseases and has attracted substantial efforts in the field of medicine. Therefore, in this review, we focus on the recent development of drug discovery targeting “undruggable” proteins and their ...
Recent efforts in biomedical prevention of HIV. 来自 NCBI 喜欢 0 阅读量: 27 作者: RJ Landovitz 摘要: Despite major advances in treatment and progress in distribution of antiretroviral therapy in the developing world, staggering rates of new persist. Innovative approaches to prevention of ...
Recent Advances in the Development of HIV-1 Vaccines Using Replication-Incompetent Adenovirus Vectors An increasing body of evidence suggests that a vaccine that elicits anti-HIV-1 cellular immunity could provide the basis for an effective AIDS vaccine. Com... JW Shiver,EA Emini - 《Annual ...
In this Review, we highlight some recent developments in the discovery and application of broadly neutralizing antibodies (bnAbs) to human immunodeficiency virus (HIV); i.e., antibodies able to neutralize diverse isolates of HIV. We consider the characte
For human immunodeficiency virus type 1 (HIV-1) vaccine development, a central focus is developing a vaccine that primarily drives strong and broad CD8+ cytotoxic T lymphocytes (CTLs). This focus is largely due to the difficulty in generating cross-neutralizing antibodies against the diverse array...