Chimeric antigen receptor (CAR) T cell therapy involves modified T cells to create distinct antibodies that can detect and cling to antigens on cancerous cells. Tumor-infiltrating lymphocyte (TIL) therapy is a potentially effective cancer treatment strategy. The application of nanoparticles in drug ...
Recent breakthroughs in cancer therapy have shown a progressive trend away from monotherapy and toward various therapeutic techniques such as synergistic bimodal and trimodal cancer therapies within a single system [3]. Outstanding advantages of nanomaterials have contributed to rapid nanotechnological develop...
Lung cancer continues to be the leading cause of cancer-related death worldwide. In the last decade, significant advancements in the diagnosis and treatment of lung cancer, particularly NSCLC, have been achieved with the help of molecular translational research. Among the hopeful breakthroughs in the...
The treatment landscape of gastric cancer has evolved significantly in the past few years, with the emergence of new immunotherapy and targeted therapies for patients at various stages of the disease (Fig.1). In this review, we systematically summarize the pivotal clinical trials in GC treatment a...
Several other aquaporins are overexpressed in a variety of cancer types (Table 1). Given the crucial role of water transport in the migration of tumor cells and of angiogenic endothelial cells, aquaporin inhibition has been suggested as a novel anticancer strategy [6]. Notably, no pharmacological...
Triple-negative breast cancer (TNBC) is the most malignant subtype of breast cancer (BC) with a poor prognosis. Current treatment options are limited to surgery, adjuvant chemotherapy and radiotherapy; however, a proportion of patients have missed the surgical window at the time of diagnosis. TNBC...
therapy resistance. Based on these mechanisms, in this section, we will discuss the promising potential of MSC-derived exosomes as a novel therapeutic strategy for enhancing therapeutic sensitivity, delivering various anticancer cargoes, and repairing radiotherapy-induced damage in cancer treatment (Fig.3...
zebrafish, showing that this technique was likely to trigger apoptosis. If this bioorthogonal-based light-controlled ion channel regulation mechanism can be applied to tumors, it is predicted to yield a new method for cancer treatment. Radiodynamic therapy (RDT) is a novel cancer treatment approach...
Metastatic colorectal cancer (mCRC) continues to be associated with a poor prognosis, and there remains a significant unmet need for novel agents and treatment regimens. Major breakthroughs have been made with immune checkpoint blockade therapy in several disease types, including DNA mismatch repair de...
Cancer immunotherapy has ushered in a new field for the treatment of various malignancies, aiming to redirect or stimulate the host’s immune system to attack proliferating tumor cells. Importantly, recent development of adoptive cell therapy (ACT) shows tremendous potential to combat tumors by using...