Cancer is a persistent global health challenge, demanding continuous exploration of innovative therapeutic strategies. Hydroxytyrosol (HT), derived from olive oil, has garnered attention for its potent antioxid
The 13 ENBDC committee members quickly reached a consensus on the greatest breakthroughs of the last decade. While some implicit bias cannot be excluded, there was unanimous agreement that the development and application of new technologies, in combination with key biological and clinical research ques...
Recent breakthroughs in cancer therapy have shown a progressive trend away from monotherapy and toward various therapeutic techniques such as synergistic bimodal and trimodal cancer therapies within a single system [3]. Outstanding advantages of nanomaterials have contributed to rapid nanotechnological develop...
Therapeutic resistance is a daunting challenge in achieving cures in patients with cancer. Cancer therapy resistance can be categorized into primary resistance and acquired resistance. Primary resistance means that tumour cells are initially resistant to standard therapy due to genetic or phenotypic alterati...
Lung cancer continues to be the leading cause of cancer-related death worldwide. In the last decade, significant advancements in the diagnosis and treatment of lung cancer, particularly NSCLC, have been achieved with the help of molecular translational research. Among the hopeful breakthroughs in the...
Several other aquaporins are overexpressed in a variety of cancer types (Table 1). Given the crucial role of water transport in the migration of tumor cells and of angiogenic endothelial cells, aquaporin inhibition has been suggested as a novel anticancer strategy [6]. Notably, no pharmacological...
Find out more about the cutting-edge work taking place at DJS Antibodies, as well as the exciting immunology and medicine breakthroughs the company hopes to acheive at its new state-of-the-art laboratory, in‘Antibodies Developer locates to Oxford Trust’s Wood Centre.'...
Cancer is a kind of serious disease that threatens the health and life of human beings [1]. The strategies for tumor therapy mainly include surgical resection, chemotherapy, and radiation therapy in clinical practice. Although these methods effectively inhibit tumor growth, improve the quality of li...
In recent years, breakthroughs in covalent inhibitors discovered through electrophile-first approaches made it possible to target KRASG12C mutants.50 Cysteine is located at codon 12 of KRASG12C, making it possible to selectively target mutant KRAS covalently. Importantly, KRAS active sites lack cyste...
While traditional cancer treatments such as surgery, chemotherapy, and radiotherapy (RT) have achieved some success in improving patient survival rates, their efficacy in treating advanced metastatic cancer remains limited. Immunotherapy has made significant breakthroughs in treating advanced cancer, yet its...