The advent of single-cell RNA sequencing (scRNA-seq) has provided insight into the tumour immune microenvironment (TIME). This review focuses on the application of scRNA-seq in investigation of the TIME. Over time, scRNA-seq methods have evolved, and components of the TIME have been deciphered...
In addition, single-cell protein expression and epigenomics can also be analysed to better understand cellular diversity and gene regulatory mechanisms. Recent reviews have concluded that the advances in these technologies [47, 48] still need improvement before wide application. High-throughput single-...
A recent study questions the effectiveness of using exosomes from adipose-derived stem cells (ADSC-Exos) in regenerative medicine. Exosome donors with metabolic problems had reduced adipose stem cell number and therapeutic potential [58]. Despite possible challenges, the utilization of exosomes derived ...
A recent study questions the effectiveness of using exosomes from adipose-derived stem cells (ADSC-Exos) in regenerative medicine. Exosome donors with metabolic problems had reduced adipose stem cell number and therapeutic potential [58]. Despite possible challenges, the utilization of exosomes derived ...
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature. 2009;459:262–5. Article CAS PubMed Google Scholar Drost J, Clevers H. Organoids in cancer research. Nat Rev Cancer. 2018;18:407–18. Article CAS PubMed Google Scholar Ballard DH, Boyer...
For this review, we will focus on advances in GGP research since 2011. This paper is organized as follows. Section 2 describes advances in the MCTS method, the state-of-the-art GGP approach, with particular focus on Monte-Carlo (MC) simulation control mechanisms. The MCTS algorithm is very...
diagnostics Review A Review of the Recent Advances in Alzheimer's Disease Research and the Utilization of Network Biology Approaches for Prioritizing Diagnostics and Therapeutics Rima Hajjo 1,2,3,* , Dima A. Sabbah 1 , Osama H. Abusara 1 and Abdel Qader Al Bawab 1 1 Department of Pharmacy...
toxins Review Aptamers and Aptasensors for Highly Specific Recognition and Sensitive Detection of Marine Biotoxins: Recent Advances and Perspectives Lianhui Zhao 1, Yunfei Huang 1, Yiyang Dong 2, Xutiange Han 1, Sai Wang 1,* and Xingguo Liang 1,3 1 College of Food Science and Engineering, ...
molecules Review Recent Advances in Bioactive Flavonoid Hybrids Linked by 1,2,3-Triazole Ring Obtained by Click Chemistry Daniela Pereira 1,2 , Madalena Pinto 1,2 , Marta Correia-da-Silva 1,2,* and Honorina Cidade 1,2,* 1 Laboratory of Organic and Pharmaceutical Chemistry (LQOF), ...
Recent advances in in vitro platforms are discussed below with an emphasis on toxicity evaluation—a significant bottleneck in drug discovery. 3. In Vitro Cellular Models for Drug Discovery The process of drug discovery and development is complex, costly, and time-consuming, typically taking between...