On the other hand, the cyclic side chain of Pro (the only proteinogenic amino acid with a constrained phi angle) is too stiff to make a regular secondary structure and therefore intrin- sically reduces the ability to form hydrogen bonds. The conformational constraint imposed by the pres- ...
Additionally, ASP 55 was found to form one hydrogen bond with TAK-285, 1d and two hydrogen bonds with 1a, with very low occupancy. On the other hand, compound 1d shown to perform one hydrogen bond with THR 90, with 52.83% which strengthen the interaction. Moreover, GLN 91 shown to ...
These interactions results from intermolecular hydrogen bonds between fluorine atoms and the hydrogen atoms connected with carbon atom in imidazole ring of EMImDFOB38 as represented pictorially in Fig. 4(b). Further, as it can be seen from the thermo- gram that the drastic weight losses of ...