On the other hand, the cyclic side chain of Pro (the only proteinogenic amino acid with a constrained phi angle) is too stiff to make a regular secondary structure and therefore intrin- sically reduces the ability to form hydrogen bonds. The conformational constraint imposed by the pres- ...
Additionally, ASP 55 was found to form one hydrogen bond with TAK-285, 1d and two hydrogen bonds with 1a, with very low occupancy. On the other hand, compound 1d shown to perform one hydrogen bond with THR 90, with 52.83% which strengthen the interaction. Moreover, GLN 91 shown to ...