Introduction: Immune tolerance induction (ITI) is the standard of care for eradication of inhibitors in subjects with severe hemophilia A. ITI is not always effective and can require a lengthy and burdensome treatment regimen. Those who have previously failed ITI are more likely to fail subsequent...
To better understand the extent of DDIs (or lack thereof) of nirmatrelvir; ritonavir in a clinical setting, this study used real-world evidence (RWE) from the Optum Clinformatics Data Mart database to identify the top 100 drugs most commonly prescribed to US patients at high risk of ...
Nevertheless, data on the large sample and real-world comprehensive safety of alglucosidase alfa are lacking. Therefore, using data mining algorithms to search for potential adverse events (AEs) of alglucosidase alfa in the real world is necessary. The FDA Adverse Event Reporting System (FAERS) ...
Although the whole of this life were said to be nothing but a dream and the physical world nothing but a phantasm, I should call this dream or phantasm real enough, if, using reason well, we were never deceived by it. — Gottfried Wilhelm Leibniz ...
Real-world data (RWD) and real-world evidence (RWE) are now being routinely used in epidemiology, clinical practice, and post-approval regulatory decisions. Despite the increasing utility of the meth...
Sismondo S. Epistemic Corruption, the Pharmaceutical Industry, and the Body of Medical Science. Front Res Metr Anal. 2021 Mar 8;6:614013 (“Put simply, if a pharmaceutical company funds a trial, the chances of results and conclusions in that company’s favor are increased.”) ...
The topological phases of non-interacting fermions have been classified by their symmetries, culminating in a modern electronic band theory where wavefunction topology can be obtained from momentum space. Recently, Real Space Invariants (RSIs) have provi
The efficiency of replication error repair is a critical factor governing the emergence of mutations. However, it has so far been impossible to study this efficiency at the level of individual cells and to investigate if it varies within isogenic cell po
These findings strongly suggest that we cannot expect outcomes of real-world ongoing tacit bargaining situations to be efficient, if efficiency requires an intertemporal behavior that is too complex relative to other behaviors that give inefficient but reasonable payoffs. Moreover, we can not deduce ...
In a sense, vision is rather superficial, since when we look around, almost always what we see is just the surfaces of opaque things of the world and little more. Skin. Clothes. Bedding. Rugs. Curtains. Furniture coverings. The floor. In the open air, the ground. Brick fronts. Bark. ...