Nanoparticle-based therapeutics represent potential strategies for treating atherosclerosis;however,the complex plaque microenvironment poses a barrier for nanoparticles to target the dysfunctional cells.Here,we report reactive oxygen species(ROS)-responsive and size-reducible nanoassemblies,formed by multivalent ...
More recently polymeric nanoparticulate systems have been designed to release drugs in response to reactive oxygen species (ROS) within the cancer cells [11]. Hydrogen peroxide (H2O2) is one of the reactive oxygen species (ROS), which plays a key role in cell signaling pathways. Metabolic ...
Aminoferrocene-based prodrugs activated by reactive oxygen species. Cancer cells generally generate higher amounts of reactive oxygen species than normal cells. On the basis of this difference, prodrugs have been developed ... H Hagen,P Marzenell,E Jentzsch,... - 《Journal of Medicinal Chemistry...
Therefore, to specifically deliver dexamethasone (Dex) to inflamed joints and reduce the administration frequency of Dex, we developed Dex-loaded reactive oxygen species (ROS)-responsive nanoparticles (Dex/Oxi-αCD NPs) and folic acid (FA) modified Dex/Oxi-αCD NPs (Dex/FA-Oxi-αCD NPs) and...
Abstract Diabetic wounds are more likely to develop into complex and severe chronic wounds. The objective of this study is to develop and assess a reactive oxygen species (ROS)‐responsive multifunctional injectable hydrogel for the purpose of diabetic wound healing. A multifunctional hydrogel (HA@Cur...
A new heterobifunctional reactive oxygen species (ROS) responsive thioketal linker and its synthesis are described. This linker allows for developing new ROS-responsive agents with two distinct functionalities using universal bioconjugation methods. The reaction kinetics of the thioketal cleavage in the ...
In situ formed reactive oxygen species-responsive scaffold with gemcitabine and checkpoint inhibitor for combination therapy. Sci. Transl. Med. 2018, 10, eaan3682. 1 Chemoimmunotherapy based on the in situ formed hydrogel scaf fold ... X Han,H Li,D Zhou,... - 《Accounts of Chemical Researc...
Elevated levels of reactive oxygen species (ROS) have commonly been implicated in a variety of diseases, including cancer, inflammation, and neurodegenerative diseases. In light of significant differences in ROS levels between the nonpathogenic and pathological tissues, an increasing number of ROS-respo...
Reactive oxygen species-responsive polymer drug delivery systems. Front Bioeng Biotechnol. 2023;11:1115603.Search in Google Scholar [20] Heidari Z, Pelalak R, Eshaghi Malekshah R, Pishnamazi M, Rezakazemi M, Aminabhavi TM, et al. A new insight into catalytic ozonation of sulfasalazine ...
et al. Salt-responsive ERF1 regulates reactive oxygen species-dependent signaling during the initial response to salt stress in rice. Plant Cell 25, 2115–2131 (2013). Article CAS PubMed PubMed Central Google Scholar Pérez-Salamó, I. et al. The heat shock factor A4A confers salt ...