Memory reprocessing following acquisition enhances memory consolidation. Specifically, neural activity during encoding is thought to be ‘replayed’ during subsequent slow-wave sleep. Such memory replay is thought to contribute to the functional reorgani
used to train the encoding models, and three sets of alternating encoding and retrieval runs (Fig.1a). During encoding runs participants memorize a sequence of color images while performing a 1-back
For each memory, the pattern looks a little different. But these webs overlap. “Every piece of knowledge that you have is related to other things,” adds Antony. So when our sleeping brain replays memories, it doesn’t just strengthen them — it embeds new information you’ve picked up...
Participants were exposed to a probabilistically determined sequence of tones and subsequently tested for recognition of novel short sequences adhering to this same statistical pattern in both immediate and delayed recall sessions. In different groups, the exposure stream was replayed during SWS in the ...
Prior work has implicated the hippocampus and medial temporal lobe cortex in memory for temporal information associated with individual episodes. However, the processes involved in encoding and retrieving temporal information across extended sequences is relatively poorly understood. Here we used fMRI ...
Reactivation of representations corresponding to recent experience is thought to be a critical mechanism supporting long-term memory stabilization. Targeted memory reactivation, or the re-exposure of recently learned cues, seeks to induce reactivation an
Salient experiences are often relived in the mind. Human neuroimaging studies suggest that such experiences drive activity patterns in visual association cortex that are subsequently reactivated during quiet waking. Nevertheless, the circuit-level consequences of such reactivations remain unclear. Here, we...
In other memory domains spontaneous post-learning activity has been linked to dopamine. Here, we show that a neural activation pattern — evoked in the ventromedial prefrontal cortex (vmPFC) by the unexpected omission of the feared outcome during extinction learning — spontaneously reappears during ...
Transposable elements (TEs) are genomic sequences having the ability to move from one location to another on the genome. They make up a large portion of eukaryotic genomes, as in Human where they account for almost 50% of the genome. The presence of TEs within genomes is dynamic. TEs tend...
Transposable elements (TEs) are genomic sequences having the ability to move from one location to another on the genome. They make up a large portion of eukaryotic genomes, as in Human where they account for almost 50% of the genome. The presence of TEs within genomes is dynamic. TEs tend...