RCAN1 (Adapt78) is an endogenous inhibitor of calcineurin, an important intracellular phosphatase that mediates many cellular responses to calcium. RCAN1 is expressed in multiple organs, especially heart, skeletal muscle and brain. In brain, it is thought to be important due to its strong ...
RCAN1;ADAPT78;CSP1;DSC1;DSCR1;MCIP1;RCN1;regulator of calcineurin 1;calcipressin-1;Down syndrome candidate region 1;Down syndrome critical region gene 1;calcium and oxidant-inducible mRNA;modulatory calcineurin-interacting protein 1;myocyte-enriched calcineurin-interacting protein 1;near DSCR proline...
RCAN1-4 induction involved calcium, calcineurin, and reactive oxygen species. Subsequent analysis with whole bacteria including gram-negative E. coli and gram-positive Staphylococcus aureus revealed strong RCAN1-4 inductions by both, and where tested, dependence on calcium. Staphylococcus aureus cell ...
The calcium influx in NMDA-R-dependent LTD allows Ca2+/calmodulin to activate calcineurin [23]. In LTP, however, calcineurin activity needs to be suppressed despite the large Ca2+ influx after NMDA-R activation [2, 3]. PKA kinase has been described to cause a suppression of calcineurin ...
蛋白别名: Adapt78; calcineurin inhibitor; Calcipressin-1; calcium and oxidant-inducible mRNA; Down syndrome candidate region 1; Down syndrome critical region gene 1; Down syndrome critical region homolog 1; Down syndrome critical region protein 1; Down syndrome critical region protein 1 homolog; MC...
A clue to the identity of the responsible gene came from our previous observations that the calcium-calmodulin-activated phosphatase, calcineurin, is necessary for NGF-dependent endocytosis of TrkA receptors, and for sympathetic innervation of target tissues34. Among the 113 trisomic genes in Dp(16)...
Plasma membrane calcium ATPase isoform 4 inhibits vascular endothelial growth factor-mediated angiogenesis through interaction with calcineurin. Vascular endothelial growth factor (VEGF) has been identified as a crucial regulator of ...
蛋白别名:Adapt78; calcineurin inhibitor; Calcipressin-1; calcium and oxidant-inducible mRNA; Down syndrome candidate region 1; Down syndrome critical region gene 1; Down syndrome critical region protein 1; Down syndrome critical region protein 1 homolog; MCIP1; modulatory calcineurin-interacting prote...
Rabbit anti Human RCAN1 antibody recognizes calcipressin-1, also known as DSC1, Down syndrome critical region gene 1, calcium and oxidant-inducible mRNA, modulatory calcineurin-interacting protein 1 or myocyte-enriched calcineurin-interacting protein 1 near DSCR proline-rich protein.The protein encoded...
Ermak G, Harris CD and Davies KJ (2002) The DSCR1 (Adapt78) isoform 1 protein calcipressin 1 inhibits calcineurin and protects against acute calcium-mediated stress damage, including transient oxidative stress. FASEB J. 16: 814–824 Article CAS PubMed Google Scholar Fuentes JJ, Genesca L,...