RBM10-TFE3 renal cell carcinoma: A potential diagnostic pitfall due to cryptic intrachromosomal Xp11.2 inversion resulting in false-negative TFE3 FISH. Am. J. Surg. Pathol. 2017, 41, 655-662. [CrossRef] [PubMed]
这些病例确认了RBM10-TFE3可在Xp11转位的肾细胞癌中重复发生,阐明了TFE3荧光原位杂交断裂探针假阴性的一个原因,突出了TFE3免疫组化和TFE3荧光原位杂交互补作用。 RBM10-TFE3 Renal Cell Carcinoma: A Potential Diagnostic Pitfall Du...
Conclusions The present study suggests that the carcinogenesis of RBM10 – TFE3 RCC in some, but not all, patients may be associated with chronic kidney disease. The aggressive nature of RBM10 – TFE3 RCC should be considered, as five patients experienced metastases.doi:10.1111/his.13866...
RBM10-TFE3renal cell carcinomatranslocation tumourRBM10-TFE3 renal cell carcinomas are a rare and recently described tumour type with a range of morphology including a biphasic pattern. There are well-known specific difficulties in establishing a diagnosis with TFE3 immunohistochemistry being ...
RNA‐binding motif protein 10 (RBM10)transcription factor E3Xp11 translocation renal cell carcinomaAims Xp11 rearrangement in renal cell carcinoma (RCC) typically involves gene fusion to the gene encoding transcription factor E3 (TFE3), a member of the microphthalmia‐associated transcription factor ...
RBM10-TFE3 renal cell carci- noma: a potential diagnostic pitfall due to cryptic intrachromosomal xp11.2 inversion resulting in false-negative TFE3 FISH. Am J Surg Pathol 2017; 41: 655-662.Argani, P.; Zhang, L.; Reuter, V.E.; Tickoo, S.K.; Antonescu, C.R. RBM10-TFE3 renal ...
Xp11 translocation renal cell carcinomas (RCC) are characterized by several different translocations involving the TFE3 gene. Tumors with different specific gene fusions may have different clinicopathologic manifestations. Only 3 RBM10-TFE3 RCCs have been reported to date. Here, we added 4 cases of...
Xp11.2转位的肾细胞癌是由Xp11断点导致染色体转位,融合伙伴通常为TFE3,TFE3断裂探针的荧光原位杂交通常首选免疫组化TFE3抗体确认,这是由于荧光原位杂交对变量固定不太敏感,从而有时会产生假阳性或假阴性.由细胞遗传学文献报道提示,作者确认3例Xp11.2转位的肾细胞癌,发现1个新的融合亚型RBM10-TFE3.TFE3重排没有被...