We next characterized the mechanism of BAY-876 impaired growth in TNBC cell lines by quantifying the impact on cell cycle and apoptosis. The BAY-876 sensitive HCC1806 and Hs 578T cell lines demonstrated a modest but significant decrease in the S phase, with a concurrent increase in G1 phase...
e Scatter plot comparing scarHRD scores in RB1-mutant (red) and RB1-normal (black) osteosarcoma cell lines. Error bars represent median ±95%CI. Data for cell lines with BRCA1,2 alteration (JOSH.3 (ovarian) (BRCA1 p.E1593*, BRCA2_p.R1751*), HCC1395 (breast) (BRCA1_p.YRRGA...