Generally speaking, E2F and Rb proteins form complexes during G1 phase of the cell cycle to repress E2F target gene expression. During G1/S and S phase, Rb–E2F complexes are disrupted by cyclin-dependent kinase activity, which leads to the release of “free” activating E2F, expression of...
The RB-reconstituted cells grew more slowly and were less invasive than the parental cells and cells infected with a firefly luciferase (LUX) gene carrying retrovirus, used as controls. RB-reconstituted cells re-explanted from the intraocular and intracranial tumors continued to express full-length ...
Entrez Gene ID:(Human) 5947,(Rabbit) 100354448,(Goat) 102189996,(Mouse) 19659,(Rat) 25056 功能 transporter activityretinoid bindingretinal bindingretinol bindinglipid binding 参与通路 retinoid metabolic processretinoic acid biosynthetic processvitamin A metabolic processtransportregulation of granulocyte differ...
Full Nameretinoblastoma 1 Calculated Molecular Weight928 aa, 106 kDa Observed Molecular Weight110 kDa GenBank Accession NumberBC039060 Gene SymbolRB1 Gene ID (NCBI)5925 ConjugateUnconjugated FormLiquid Purification MethodAntigen affinity purification ...
(IL20RB) is a single-pass type I membrane protein of the type II cytokine receptor family. The interleukin-20-receptor I complex (IL-20-RI) is composed of two chains, IL20RA and IL20RB. IL-20-RI is a receptor for IL-19, IL-20 and IL-24. IL20RB can also form a heterodimer ...
receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on ...
Mouse fibroblasts lacking RB1 function form spheres and undergo reprogramming to a cancer stem cell phenotype. Cell Stem Cell 4, 336–347 (2009). Article PubMed PubMed Central CAS Google Scholar Akamatsu, S. et al. The placental gene PEG10 promotes progression of neuroendocrine prostate cancer...
increasing both DNA binding and transcriptional function on their respective response elements. The gene lies within the major histocompatibility complex (MHC) class II region on chromosome 6. An alternatively spliced transcript variant has been described, but its full length sequence has not been deter...
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