The Rb protein is a tumor suppressor, which plays a pivotal role in the negative control of the cell cycle and in tumor progression. It has been shown that Rb protein (pRb) is responsible for a major G1 checkpoint, blocking S-phase entry and cell growth. The retinoblastoma family includes...
由此可见，RB作用机制的模型需要更新，需要一个融合了RB的经典和非经典活性的新模型。2022年8月17日，来自美国哈佛医学院的Michael S. Lawrence团队在Molecular Cell上在线发表题为Chromatin-bound RB targets promoters, enhancers, and CTCF-bound loci and is redistributed by cell-cycle progression 的文章，首次确...
These mutations promote tumour development by deregulating the E2F family of transcription factors leading to uncontrolled cell cycle progression3. We show that the mitotic checkpoint protein Mad2 is a direct E2F target and, as a consequence, is aberrantly expressed in cells with Rb pathway defects...
enhancers, and CTCF-bound loci and is redistributed by cell-cycle progression的文章,首次确定了RB结合染色质的全谱,发现RB不是只靶向E2F启动子,而是可以与特定的启动子、增强子和绝缘子组相关联,以靶向不同的基因。同时
complex formation and their binding to E2F sites in target promoters. Many target genes are downregulated as a consequence of this mechanism of indirect p53-dependent transcriptional repression. As most repressed genes are involved in cell cycle progression, their downregulation causes cell cycle arrest...
The product of the MTS1/CDKN2 gene (p16) and the retinoblastoma protein (pRB) inhibit cell cycle progression at the late G1 checkpoint. The absence of functional p16 or pRB has been identified in a variety of human tumors but has not been well studied in mesenchymal neoplasia. Using an ...
RB itself is nonessential for cell cycle control (Jacks, 1996), and its actual role in governing cell cycle progression in different physiologic settings remains unresolved. For example, recruitment of HDACs to E2F-responsive promoters in normal fibroblasts is largely controlled by p107 and p130 ...
4.Rb can act as a key brake on cell-cycle progression, and it promotes cellular differentiation into specific cell types, which slows the development of cancer. 5.Rb exerts its regulatory influence on other positive regulator proteins.
RB and cell cycle progression The Rb protein is a tumor suppressor, which plays a pivotal role in the negative control of the cell cycle and in tumor progression. It has been shown that... C Giacinti,A Giordano - 《Oncogene》 被引量: 1195发表: 2006年 Distinct mechanisms control the accum...
RB and its structurally and functionally related family members, p107 and p130, have similar properties of binding to the E2F family members and of inhibiting cell cycle progression when ectopically expressed (17). The E2F family of proteins includes both the transcriptional activators (E2F1, E2F2...