RANKL and RANK are members of the TNF superfamily of ligands and receptors that play an important role in the regulation of specific immunity and bone turnover. RANK (receptor) was originally identified as a dendritic cell-membrane protein, which, by interacting with RANKL, augments the ability ...
TNF Superfamily Ligands Related Products All Products for Fas Ligand/TNFSF6 Fas Ligand/TNFSF6 Primary Antibodies Fas Ligand/TNFSF6 Proteins and Enzymes Fas Ligand/TNFSF6 ELISAs Fas Ligand/TNFSF6 Simple Plex Assays Fas Ligand/TNFSF6 cDNA Clones Associated Pathways Apoptosis Signaling Pathways...
RANKL and RANK are members of the TNF superfamily of ligands and receptors that play an important role in the regulation of specific immunity and bone turnover. RANK (receptor) was originally identified as a dendritic cell-membrane protein, which, by interacting with RANKL, augments the ability ...
cells and a range of non-endothelial cells. Although VEGF affinity is highest for binding to VEGF R1, VEGF R2 appears to be the primary mediator of VEGF angiogenic activity (3, 4). VEGF165also binds the semaphorin receptor, neuropilin-1, which promotes complex formation with VEGF R2 (18)....
The activation of TGR5 by bile acids or synthetic ligands is reported to play a role in metabolic homeostasis, including alleviating inflammatory responses, improving glucose tolerance in obesity and diabetic mice, and stimulating energy expenditure in brown adipose tissues. In the kidney, TRG5 ...
AhR signaling represents one of the essential pathways in xenobiotic metabolism and physiology of oval cells. It has been reported, that this transcription factor can be activated by second messenger cAMP, which plays a crucial role not only in liver metabolism. We therefore tested if AhR and ...
systemic endothelial cells and various types of leukocytes16,17. Interaction between RAGE and its ligands such as HMGB-1 has been implicated in the activation of multiple signalling pathways for immune responses and the subsequent development of SIRS associated with sepsis and acute lung damage11,18...
Compare to the control group, higher expression of p65, IL-6, TNF-α, and ratio of p-IκBα/IκBα were noted in TG group indicating the activation of NF-κB pathway and associated inflammatory response may relate to ER stress. However, liraglutide treatment inhibited the activation of NF...
specific Tregs. It has been suggested that Treg may recognize distinct tolerogenic fragments in Tg (Bagchiet al., 1996) that may have a low iodine content (Gardineet al., 2003), but the natural ligands for Tg-specific Treg have not been identified and it remains unknown whether they contain...
Tumor necrosis factor receptor-1 (TNF-R1) and other TNF receptor superfamily members, such as DR3, contain intracellular death domains (DD) and are capable of initiating apoptosis when activated by their ligands. Silencer of Death Domains (SODD) was identified as being involved in the cellular...