Kinship behavior in the rat was first demonstrated by Hepper, who showed that from birth, pups recognize and respond preferentially to genetic relatives7,8. Similar to Hepper, we built a two-chamber apparatus connected by a center T-tube where air was blown through each box to the center of...
86 During each inter-trial interval, animals were removed from the arena and transferred back to the homecage, and the arena was cleaned to remove uncontrolled intra-maze non-visual cues. In some sessions, cells from four of the six implanted rats were additionally recorded in the same square...
The neurobiology of memory continues to attract the attention of researchers in several disciplines. Memory is being studied at the molecular, cellular, systems, and organismic levels in experimental animals (Matthies, 1989). Additionally, advances in ne
Using a variety of delivery methods, including direct protein, stem cell and viral, GDNF has been shown to protect dopamine and motor neurons in a number of animal models.23–26 GDNF delivered into the spinal cord protected spinal motor neurons in ALS rats; however, it did not preserve ...
Under a Creative Commons license Open accessAbstract Using a novel rat model of Down syndrome (DS), the functional role of the cystathionine-β-synthase (CBS)/hydrogen sulfide (H2S) pathway was investigated on the pathogenesis of brain wave pattern alterations and neurobehavioral dysfunction. Increase...
Studies of the distribution of fluorescent-labeled Aβ1-42 in the brain showed that soluble Aβ-species diffused into all parts of the rat brain. After seven days, the Aβ-treated animals showed a significant decrease of spatial memory in Morris water maze test and impairment of synaptic ...