CELL permeabilityAdvanced glycation end-products (AGEs) are formed by the non-enzymatic reaction of sugars and proteins. Among the AGEs, glyceraldehyde-derived toxic AGEs (TAGE) are associated with various diseases, including diabetic complications such as diabetic retinopathy (DR). The risk of ...
Expression of endogenous RasGRP2 in TERT HUVECs and suppression by endogenous RasGRP2 of the decreased cell viability. (a,b) Each effect was detected using western blotting. (a) RasGRP2 was detected using a specific antibody. R: RasGRP2-stable overexpression cells. (b) Activated R-Ras was...
mastocytosis,and mast cell leukemia patients and demonstration of the importance of RasGRP4 in mast cell development and function[J].J Biol Chem,2002,277
Here we demonstrate that lymph node (LN)-derived CLL cells possess a distinct phenotype and exhibit enhanced capacity for T-cell activation and superior immune synapse formation when compared to paired peripheral blood samples (PB)...doi:10.1182/bloodadvances.2017014506Silvia MeleStephen...
RasGRP4,a new mast cell-restricted Ras guanine nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs.Identification of defective variants of this signaling protein in asthma,mastocytosis,and mast cell leukemia patients and demonstration of the importance of RasGRP4 in mast cell ...
receptors regulate the Ras Binding Domains of the PIP3-generating, class I PI3Ks remain poorly understood, despite their importance in a range of biological settings, including tumorigenesis, activation of neutrophils by pro-inflammatory mediators, chemotaxis of Dictyostelium and cell growth in ...