Gene ID (NCBI) 9462 RRID AB_2879005 Conjugate Unconjugated Form Liquid Purification Method Antigen affinity purification UNIPROT ID Q9UJF2 Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Storage Conditions Store at -20°C. Stable for one year after shipment. Aliquoting is...
The protein encoded by this gene is able to complement the defective RasGAP function in a yeast system. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. 仅用于科研。不用于诊断过程。未经明确授权不得转售。
The RasGAP gene, RASAL2, is a tumor and metastasis suppressor. Cancer Cell 2013;24:365-378.McLaughlin SK, Olsen SN, Dake B, De Raedt T, Lim E, Bronson RT, et al. The RasGAP gene, RASAL2, is a tumor and metastasis suppressor . Cancer cell . 2013; 24 ( 3 ): 365–378. doi:...
The gene encoding RASAL2 is located on chromosome 1 within the prostate cancer susceptibility locus. This suggests that a mutation or defect in RASAL2 is implicated in carcino- genesis. Two transcript variants exist for RASAL2 due to alternative splicing events.Walker...
(GAPs). GAPs function as activators of Ras superfamily of small GTPases. The protein encoded by this gene is able to complement the defective RasGAP function in a yeast system. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by...
Lentivirus-overexpressing RASAL2 and scramble control were obtained from GeneCopoeia (Guangzhou, China), and viral supernatant was incubated with target cells for 12 h with 8 μg/ml polybrene following the manufacturer's instructions. Colony formation assay. Cells were seeded into a six-well plate...
Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. Applications: ELISA, WB Name of antibody: RASAL2 Immunogen: Fusion protein of human RASAL2 Full name: RAS protein activator like 2 Synonyms: NGAP SwissProt: Q9UJF2 ELISA Recommended ...
15 To date, no mutations have been identified in the ECT2 gene in astrocytomas. Interestingly, astrocyte progenitors also express cytoplasmic ECT2, although the functional significance of this is unknown. Given that our studies revealed a function for ECT2 in migration and invasion, it is ...
the related studies on the function of RASAL2 gene in tumor development and progression.【Key words】RASAL2;Malignant tumors; Oncogenesis and progression; Function 恶性肿瘤的发生和发展是多种因素共同作用的结果。在分子水平，既有突变导致的抑癌基因失活和原癌基因的激活，也涉及到复杂的表观遗传改变。
RASAL2, a unique RAS GTPase-activating protein (RAS-GAP), has been reported as a tumor-suppressor gene, which inhibits tumor progression in different types of cancer, such as luminal B breast cancer, ovarian cancer, lung cancer, nasopharyngeal carcinoma, and colorectal cancer8,9,10,11,12. In...