(ii) 2.1% rasagiline mesylate by weight of the composition;63.3% by weight of the composition of a mixture of a disintegrant, a flow agent and particles having a non-filamentous microstructure of at least two sugar alcohols;25.7% xylitol by weight of the composition;0.3% silicon dioxide by ...
The method solvesthe problems of high cost due to the adoption of a key intermediate R-1-indamine, low reaction yield, long reaction steps and disadvantage on industrialized production in the conventional rasagiline mesylate synthesis process.乔建成...
The present invention relates to an anti-drug rasagiline mesylate Parkinson's disease new preparation method, belonging to the technical field of the preparation rasagiline mesylate. 它是以1-茚酮(II)为原料,引入手性助剂并还原,反应得到化合物(III);然后将得到的化合物(III)与3-卤丙炔反应得到化合物(IV...