Ras-related protein Ral-A (RalA)
Here we searched for a role of this protein in spine morphogenesis. We found that it is enriched in dendritic spines of cultured hippocampal pyramidal neurons during early stages of development. Rich2 specifically stimulated the Rac1 GTPase in these neurons. Inhibition of Rac1 by EHT 1864 ...
Hofmann F, Rex G, Aktories K, Just I (1996) The ras-related protein Ral is monoglucosylated by Clostridium.sordrllii lethal toxin. Biochem Biophys Res Commun 227: 77–81Hofmann F, Rex G, Aktories K, Just I (1996) The ras-related protein Ral is monoglucosylated by Clostridium sor...
Human cDNAs coding for the new protein ral that shares 50% homology with the ras proteins have been recently isolated. A 600-bp fragment carrying mainly the coding region was used to localize the ral gene by hybridization with sorted chromosomes and in situ hybridization. Direct molecular ...
The gene codes for a 206 amino acid protein of expected mol. wt 23.5 kd that shares greater than 50% homology with H-, K-or N-. The regions of and a C-terminal cysteine involved in anchoring are also present in ; this strongly suggests that is a with . Furthermore, several external...
The most interesting GEF is Epac, an exchange protein directly activated by cAMP, thus representing a novel cAMP-induced, protein kinase A-independent pathway. Furthermore, Rap1 is inactivated by specific GTPase-activating proteins (GAPs), one of which is regulated through an interaction with G伪...