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A novel ras-related GTP-binding protein (rab26) with unique structural features and predominant expression in testisAndreas BrauersAnnette SchürmannS. MassmannP. MühlZürbesHansGeorg Joost
Pancreatic adenocarcinoma (PAAD) is a frequent type of cancer in adults worldwide, and the search for better biomarkers is one of the current challenges. Although RAB7A is associated with tumour progression in multiple tumour types, there are only a few
The role of the Ras-related GTP-binding protein, Rab1B, in intracellular trafficking of β-amyloid precursor protein (βAPP) was studied in cultured 293 cells. βAPP is processed via one of two alternative routes. In the major secretory pathway,βAPP is cleaved by α-secretase within the ...
RegisterLog in Sign up with one click: Facebook Twitter Google Share on Facebook RAB12 (redirected fromras-related protein Rab-12) RAB12 A gene on chromosome 18p11.22 that encodes a member of the Rab subfamily of Ras-related small GTPases, which is involved in vesicle trafficking. ...
Finally, it should be noted that the C-terminal domain of the protein, which is probably unrelated to GTP-binding, is considerably larger than that of all other known mammalian members of the Ras family. This domain contains a stretch of hydrophobic amino acids(259-276) that was identified ...
RAB26-relatedRab26RT-PCRRH mappingChromosome 16p13.3Virtual transcribed sequence (VTSMembers of the RAB protein family are important regulators of vesicular fusion and trafficking. A putative new member of the RAB family of genes was identified through a public database search, and its full-length...
The predicted 218 amino acid R- ras protein has an amino-terminal extension of 26 residues compared with H- ras p21, and shows 55% amino acid identity; conserved domains include the p21 GTP-binding site and the carboxy-terminal membrane localization sequence. R- ras has at least six exons,...
Rem mRNA is expressed predominantly in skeletal and cardiac muscle, lung, and kidney, and the bacterially expressed protein is shown to bind GTP in a specific and saturable manner. Because other members of the RGK family are transcriptionally regulated, we examined whether a similar method of ...
In contrast, no GTP-binding activity could be observed for the rab6 T27N protein. To detect the endogenous GTPase activity, isolated rab6 wt and rab6 Q72R proteins were preloaded with [c~-32p]GTEAfter incubation for different times at 37°C the conversion of GTP to GDP was determined ...