K-ras、p-JNK、c-Jun和cyclin D1的表达;进一步采用Western blot和免疫组化法验证NGX6在体内对上述关键分子表达的影响,发现NGX6可抑制裸鼠移植瘤组织中EGFR、K-ras、p-JNK、c-Jun和cyclin D1的表达,与体外结果一致.上述研究表明,NGX6在结肠癌中主要通过抑制EGFR介导的JNK通路的活性而发挥其抑瘤作用,该研究为...
有趣的是,K-ras Codon13有突变的大肠癌组织及细胞株内MAPK活性均低于正常组织。这些都提示此类型大肠癌的癌变可能是通过不同于Ras/MAPK途径的其它方式(JNK?)发生的;与K-ras有关的MAPK及JNK信号传导蛋白激酶可能参与了大肠癌的发生,可能会对大肠癌的分期、病理类型、转移和预后的判定提供分子生物学依据,对这些问题...
JNK activation by R-RasVal-38 was inhibited by a dominant-negative mutant of mixed lineage kinase 3. Among six GEFs for Ras-family G proteins, mSos1, Ras-GRF, C3G, CalDAG-GEFI, Ras-GRP/CalDAG-GEFII, and Epac/cAMP-GEFI, GEFs for either H-Ras or R-Ras activated JNK and c-Jun-...
Furthermore, consistent with our hypothesis, we found that inhibition of JNK activity by expression of a dominant-negative form of Drosophila JNK homolog Basket (BskDN) completely abolished RasV12/fmt−/−-induced tumor growth, invasive phenotype, and JNK activation (Figures 2L, 2M, and S2C...
(2016). Rasfonin promotes autophagy and apoptosis via upregulation of reactive oxygen species (ROS)/JNK pathway. Mycology: Vol. 7, No. 2, pp. 64-73. doi: 10.1080/21501203.2016.1170073doi:10.1080/21501203.2016.1170073Wang, WeijunSun, Hui...
Furthermore, JNK activity is increased in the ventricles of mice overexpressing oncogenic Ras, whereas ERK activity is not. These results suggest that the alpha1-AdrR mediates ANF gene expression through a Ras-MEKK-JNK pathway and that activation of this pathway is associated with in vitro and ...
reported herein demonstrate that these agonists stimulate DNA synthesis in primary cultures of rat hepatocytes via a Ras/Rac1/Cdc42/SEK/JNK/c-Jun–dependent mechanism. Our data also demonstrate that the ability of cells to sense al-terations in osmolarity lies at the level of the plasma ...
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