Given that Gag is a polyprotein cleaved by viral PR into the subdomains, matrix (MA/p17), apsid (CA/p24), p2, nucleocapsid (NC/p7), p1 and p6, we mapped the Gag domain involved in the block to SG assembly. Three deletion mutants containing different Gag subdomains (MA, CA and p2-...
We report here the identification of a new human cDNA clone, IQGAP1, which predicts a 1657-amino acid protein that displays extensive sequence similarity to the catalytic domain of all previously reported RasGAPs. IQGAP1 is most closely related to the Schizosaccharomyces pombe RasGAP-like protein...
The Ability of GAP1IP4BP To Function as a Rap1 GTPase-Activating Protein (GAP) Requires Its Ras GAP-Related Domain and an Arginine Finger Rather than an As... GAP1IP4BP is a member of the GAP1 family of Ras GTPase-activating proteins (GAPs) that includes GAP1m, CAPRI, and RASAL....
别名IQ motif containing GTPase activating protein 3; IQGA3_HUMAN; IQGAP 3 ; IQGAP3; MGC10170; MGC10831; MGC1947 antibodyOTTHUMP00000031854 ; OTTHUMP00000031855; Ras GTPase activating like protein IQGAP3; Ras GTPase-activating-like protein IQGAP3. ...
SHIP has previously been shown to associate via its SH2 domain (Liu et al. 1997) with some phosphorylated ITAM- (36, 20) and ITIM-containing receptors (8, 13) and to become tyrosine phosphorylated. This event has been shown to lead to association of SHIP with the adaptor protein Shc (...
To crystallize the LepBdrancourtii GAP domain-Rab1 com- plex, LepBdrancourtii GAP domain was mixed with GDP-loaded Rab1 at the molar ratio of 1:1.1 in a buffer containing 20 mM Tris-HCl (pH 8.0), 150 mM NaCl, 20 mM NaF, 2 mM AlCl3, 5 mM MgCl2 and 2 mM DTT, and the ...
(2000). Identification of a novel protein complex containing annexin VI, Fyn, Pyk2, and the p120(GAP) C2 domain. FEBS Lett. 469, 88–92.10.1016/S0014-5793(00)01252-7Search in Google Scholar Chow, A. and Gawler, D. (1999). Mapping the site of interaction between annexin VI and the...
Molecular modelling and site-directed mutagenesis of the IP-binding PH domain from the Ras GTPase-activating protein GAP1 Presents information on a study which establishes a human erythroleukemia cell line to determine the role of the inositol 1,3,4,5-trisphosphate-binding pro... G Cozier,RB ...
RasGAP is a multifunctional protein that controls Ras activity and that is found in chromosomal passenger complexes. It also negatively or positively regulates apoptosis depending on the extent of its cleavage by caspase-3. RasGAP has been reported to bind to G3BP1 (RasGAP SH3-domain-binding ...
PH domainβγ subunitsrasThe noncatalytic domain of Ras-GAP can affect signaling through G protein-coupled receptors by a poorly understood mechanism. 2. In this study, fusion proteins containing elements of the noncatalytic domain ofras-GAP were examined for their ability to bindβγ subunits of...