RasGAP is a multifunctional protein that controls Ras activity and that is found in chromosomal passenger complexes. It also negatively or positively regulates apoptosis depending on the extent of its cleavage by caspase-3. RasGAP has been reported to bind to G3BP1 (RasGAP SH3-domain-binding ...
SHIP has previously been shown to associate via its SH2 domain (Liu et al. 1997) with some phosphorylated ITAM- (36, 20) and ITIM-containing receptors (8, 13) and to become tyrosine phosphorylated. This event has been shown to lead to association of SHIP with the adaptor protein Shc (...
Pyk2 has no SH2 or SH3 domains, but it is proposed that proline-rich stretches in the C-terminus act as ligands for SH3 domain–containing signaling proteins. Pyk2 is constitutively expressed in human T cells and is rapidly phosphorylated on the activation of TCR. This is associated with ...
Triple-negative breast cancer (TNBC) is an aggressive and heterogenous breast cancer subtype. RASAL2 is a RAS GTPase-activating protein (GAP) that has been associated with platinum resistance in TNBC, but the underlying mechanism is unknown. Here, we sho
To crystallize the LepBdrancourtii GAP domain-Rab1 com- plex, LepBdrancourtii GAP domain was mixed with GDP-loaded Rab1 at the molar ratio of 1:1.1 in a buffer containing 20 mM Tris-HCl (pH 8.0), 150 mM NaCl, 20 mM NaF, 2 mM AlCl3, 5 mM MgCl2 and 2 mM DTT, and the ...
(FERM)-domain-containing proteins talin A and B, myosin VII, and FrmA–C, have also been associated with the regulation of cell–substratum adhesion inD. discoideum[14,15,16,17,18,19]. Talin A forms a complex with myosin VII [20], which is incorporated into ventral focal adhesion ...
中文名称: RasGTP酶激活蛋白IQGAP3抗体IQGAP3 英文名称:IQGAP3 别名:IQ motif containing GTPase activating protein 3; IQGA3_HUMAN; IQGAP 3 ; IQGAP3; MGC10170; MGC10831; MGC1947 antibodyOTTHUMP00000031854
The FERM domain of merlin can directly interact with Ras Full size image Merlin interacts with Ras in vivo Merlin interacts with RasGAP Full size image Merlin interacts with RasGAP predominantly at the plasma membrane Both the FERM and the tail domains of merlin interact with RasGAP ...
G3BP2 is composed of an N-terminal domain homologous to the NTF2 protein, followed by an acidic domain sufficient for the interaction with the IκBα cytoplasmic retention sequence, a region containing five PXXP motifs and a C-terminal domain containing RNA-binding motifs. Overexpression of G...
The limit functional domain of the Cdc42-GAP protein did not compete with p180 or p175 for binding to Cdc42. However, the Cdc42-binding domain from mPAK-3, a member of the PAK (p21 activated kinase) family of serine/threonine kinases, competed with both proteins. The binding of p180 ...