由于迄今为止尚未找到 EGFR 单抗的确切靶点,这个筛选过程主要是排除无效人群,因此, KRAS、 RAS 等标志物也就被称为“ 负性标志物”。基于药物作用机制及前期发现,目前业界相信, EGFR 信号传导通路上的任何一个节点突变,都有可能对抗 EGFR 治疗带来负...
(8/20)and 50%(3/6)in stage 1,2,3 and4,respectively (P0.001).Conclusions The present data suggested that high expression of ras in osteosarcona tissues was related to the tumor clinical stage.It may be used as a maker of osteosarcoma of the bone for the tumer stage diagnosis and ...