RAS是所有癌症中最常突变的癌基因之一,其突变(RASmut,最常见于NRAS或KRAS基因)通常在急性髓系白血病(AML)病程后期或复发时获得。抗凋亡蛋白BCL2选择性抑制剂维奈托克(Venetoclax,VEN)是最近美国食品和药物管理局(FDA)批准的用于治疗AML的药...
Crystal Structure of M-Ras Reveals a GTP-bound \"Off\" State Conformation of Ras Family Small GTPases Although some members of Ras family small GTPases, including M-Ras, share the primary structure of their effector regions with Ras, they exhibit vastly dif... M Ye,F Shima,S Muraoka,...
对于RAS野生型的晚期结直肠癌的靶向治疗,来自肿瘤学年鉴中文版编委、中国医学科学院肿瘤医院的周爱萍教授为我们梳理了一线、二线以及后线靶向治疗的要点。 周爱萍教授认为,为RAS野生型的转移性结直肠癌选择治疗药物,就是处理好肿瘤微环境的调整以及...
[Methods in Enzymology] Small GTPases and Their Regulators, Part A: RAS Family Volume 255 || [1] Refolding and purification of ras proteins 来自 onAcademic 喜欢 0 阅读量: 24 作者:Campbell-Burk,L Sharon DOI: 10.1016/S0076-6879(95)55003-8 ...
[Methods in Enzymology] Small GTPases and Their Regulators, Part A: RAS Family Volume 255 || [26] Cell-free assay system for Ras-dependent MEK activation 来自 onAcademic 喜欢 0 阅读量: 19 作者:Kuroda,Shinya DOI: 10.1016/s0076-6879(95)55028-3 ...
255: Small GTPases and their regulators. Part A: Ras family: 1995, 548 pp., Price $99 Methods in Enzymology (Regulators and Effectors of Small GTPases, Part F: Ras Family I, 332)The critically acclaimed laboratory standard for more than ... S Watson - 《Neuroscience》 被引量: 0发表...
255: Small GTPases and their regulators. Part A: Ras family: 1995, 548 pp., Price $99 Methods in Enzymology (Regulators and Effectors of Small GTPases, Part F: Ras Family I, 332)The critically acclaimed laboratory standard for more than ... S Watson - 《Neuroscience》 被引量: 0发表...
[Methods in Enzymology] Small GTPases and Their Regulators, Part A: RAS Family Volume 255 || [44] Detection of point mutations in Ras in tumor cell lines by denaturant gradient gel electrophoresis 来自 onAcademic 喜欢 0 阅读量: 19
[Methods in Enzymology] Small GTPases and Their Regulators, Part A: RAS Family Volume 255 || [29] Assay and expression of mitogen-activated protein kinase, MAP kinase kinase, and Raf 来自 onAcademic 喜欢 0 阅读量: 35 作者:Alessi,R Dario ...
[Methods in Enzymology] Small GTPases and Their Regulators, Part A: RAS Family Volume 255 || [17] Measurements of GTP/GDP exchange in permeabilized fibrobl... D Vries-Smits,MM Alida 被引量: 0发表: 1995年 Measurement of GTP-bound Ras-like GTPases by activation-specific probes. This ...