影响RAS–RAF–MEK–ERK通路组分的突变,包括各种RTK、SHP2、NF1、RAS蛋白、RAF家族成员或MEK1/MEK2,可导致该通路异常激活并致癌。RAS突变或扩增是人类癌症中最常见的突变:KRAS最常发生改变,尤其是在实体肿瘤中;NRAS突变存在于黑色素瘤和许多血液恶性肿瘤中;HRAS突变...
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目的:研究肠道非霍奇金恶性淋巴瘤的EB病毒感染,p53,p21ras 蛋白表达及其相关性.方法:应用单克隆抗体CD45RO),CD20,CD78a,CD45RA,CD56,LCA,CD30,CD15,CD5, CD8,TIA-1,GramB,p53,p21;多克隆抗体CD3,κ,λ对瘤细胞进行免疫组化标记,用SABC免疫组化的方法检测瘤细胞p53, p21ras基因的表达及EB病毒寡核苷酸探针...
The c-Ha-ras-1 locus in 104 breast cancer patients and 56 unaffected individuals was examined for allelic restriction fragment-length polymorphism. Four common and 16 rare alleles were detected in the combined populations. The distributi... R Lidereau,C Escot,C Theillet,... - 《J Natl Cance...
The animals were randomly divided into four groups as follows: faunated + control diet (F); defaunated + control diet (D); faunated + experimental diet (F+E); and defaunated + experimental diet (D+E). The groups F and D were fed with a control concentrate diet containing plant ...