OPTIMOX2 研究则显示 ,与停药观察相比 ,保留 5-FU/LV 维持治疗的疗效结果较好[9]. 靶向药物疗效确切,不良反应相比传统化疗药 物较低,符合维持治疗策略的药物选择要求,靶向 维持方案由此受到关注.多项Ⅲ期研究证实,化疗 联合贝伐珠单抗诱导治疗后,继以氟尿嘧啶类药物 联合贝伐珠单抗维持治疗有疗效获益 .[11,28-...
[12]Wasan H, Meade AM, Adams R, et al. Intermittent chemotherapy plus either intermittent or continuous cetuximab for first-line treatment of patients with KRAS wild-type advanced colorectal cancer (COIN-B): a randomised phase 2 trial[J]. Lancet Oncol, 2014, 15(6):631-639. DOI: 10.1016...
X-ray Bolometric Xray erg s−1 kpc−2 Compton-y Parameter SZ dimensionless Table 1. Open in new tab Data set units and the labels used throughout this paper. SignalLabelUnits Total mass density (DM+baryons) total_mass h−1 M⊙ kpc−2 X-ray Bolometric Xray erg s−1 kpc...
Affimer K3 fulfills these criteria with the aromatic ring of W44 extending into this subpocket and its surrounding residues, S40 and D42 forming the necessary hydrogen bonds, thus the SII/α3 pocket shares a key subpocket with the SII pocket. Indeed, K3 also forms hydrogen bonds with H...
2001;4(2):229–36. CAS PubMed Google Scholar Abe Y, Suzuki T, Ono C, Iwamoto K, Hosobuchi M, Yoshikawa H. Molecular cloning and characterization of an ML-236B (compactin) biosynthetic gene cluster in Penicillium citrinum. Mol Genet Genomics. 2002;267(5):636–46. Article CAS PubMed ...
https://doi.org/10.1007/s40808-022-01507-2 Article Google Scholar Gumbel EJ (1942) On the frequency distribution of extreme values in meteorological data. Bull Am Meteorol Soc 23(3):95–105 Article Google Scholar Hagos YG, Andualem TG, Yibeltal M, Mengie MA (2022) Flood hazard ...
SARS, SARS2: Runaway RAS Silent Hypoxia: RAS in the Right Places “Atypical” ARDS: RAS “Mismatched” Extreme Mortality Rates in Ventilated COVID Patients: The Final Straw The Kidneys and Heart in COVID: Sword versus Shield Hypercoagulability and Strokes in COVID: Sabotage by RAS Higher CO...
OPTIMOX2 研究则显示 ,与停药观察相比 ,保留 5-FU/LV 维持治疗的疗效结果较好[9]. 靶向药物疗效确切,不良反应相比传统化疗药 物较低,符合维持治疗策略的药物选择要求,靶向 维持方案由此受到关注.多项Ⅲ期研究证实,化疗 联合贝伐珠单抗诱导治疗后,继以氟尿嘧啶类药物 联合贝伐珠单抗维持治疗有疗效获益 .[11,28-...