SHOC2 was recently identified as one of five genes necessary for proliferation of RAS mutant AML relative to RAS-wild-type AML (the others were RCE1, ICMT, CRAF, and PREX1) (Wang et al., 2017), further underscoring the importance of MRAS/SHOC2/PP1c in RAS signaling. Download: ...
At this point, the type of fistula was anatomically confirmed, although pre-operative imaging usually allowed this to be known in advance. Each fistula was treated “as is” and the technique was not altered for intersphincteric, transsphincteric, or suprasphincteric by type. The technique was...
Through a series of CRISPR/Cas9 screens in autochthonous lung cancer models, we show that HRAS and NRAS are suppressors of KRASG12D-driven tumour growth in vivo and confirm these effects in oncogenic KRAS-driven human lung cancer cell lines. Mechanistically, RAS paralogues interact with oncogenic...
The transformation was conducted according to [96, 97] with the deviation that fungal cultures were pre-grown on CM-agar plates and that for co-cultivation of bacteria and fungi, not cellophane or agar-blocks were used, but 200µL of a 1:1 mixture of a fungal spore solution (1 ×...
The automatic test circuit comprises a test command signal generation stage for generating a test command signal in response to an external row address strobe signal, an external column address strobe signal, an external write signal and an external read signal, a row address signal generation ...
(w/v) glutaraldehyde. GFP anchored to the PM sheets was probed with 4.5 nm gold particles pre-coupled to anti-GFP antibody. Following embedment with methyl cellulose, the PM sheets were imaged using transmission electron microscopy (JEOL JEM-1400). Using the coordinates of every gold particle...
Our pre- specified analytical criteria did not allow variables with statistical significance X0.1 to enter the multivariate model. As a consequence, the models differed and this may have affected the results. Similar constraints apply to the comparison with data by Vauthey et al (2013) that were...
International Journal of Molecular Sciences Article Inhibition of Breast Cancer Cell Invasion by Ras Suppressor-1 (RSU-1) Silencing Is Reversed by Growth Differentiation Factor-15 (GDF-15) Vasiliki Gkretsi 1,2,*, Maria Louca 2, Andreas Stylianou 2, George Minadakis 3,4, George M. Spyrou 3...
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In addition to the usual request (req) and response (res) objects, we now pass an additional object callednext(). Invokingnext()will pass the request on to whatever function is next in line to handle it. When there are a series of middleware function called one after the other it is ...