123、在n2气氛下,向(2s,6s)-4-[7-氯-8-氟-2-(1,2,3,5,6,7-六氢吡咯烷-8-基甲氧基)吡啶并[4,3-d]嘧啶-4-基]-2,6-二甲基-哌嗪-1-羧酸叔丁酯(190mg,0.355mmol)和2-(8-氯-1-萘基)-4,4,5,5-四甲基-1,3,2-二氧杂硼烷(154mg,0.533mmol)在二噁烷(5ml)和水(1ml)的溶液中加入[2-...
图10.用3g4对k-ras4b进行的biacore实验;表面等离子体共振(spr)和fortebio/octet实验显示3g4和6b9片段(lb9)在k-ras4b是否具有次级非共价相互作用位点;实验应显示化合物是否与k-ras4b在2个位点(例如,为caax-盒半胱氨酸的共价位点和非共价位点)相互作用;用k-ras4bg12v/c185s进行的spr实验,使得仅可能非共价相互...
日立(HITACHI)这款型号为RAS/C-50NVNX的壁挂式空调,其属于NX系列,空调制冷匹数为2P,整机采用了全直流变频设计,可实现精准控温以及高制冷制热量,制冷量可达5200W,制热量可达8300W,APF变频能效比达到了4.07,达到了新国标二级能效标准。每小时最高820m3循环风量(制热),可满足18-32㎡的居室使用。为方便后续使用,带有...
分子式:C46H60N8O5S 分子量:837.08 了解化合物详情 快速询单国内供应商 Pan-RAS-IN-2 数据 Mol: 3034673-92-9.mol by:chem960.com ChemDraw08031019472D ……… 0 0 0 0 7.5000 -10.3500 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.3333 -3.8000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9....
CBNumber: CB211845498 分子式: C44H58N8O5S 分子量: 811.06 MOL File: 2765081-21-6.mol 化学性质安全信息用途供应商45 RAS-IN-2化学性质 密度: 1.37±0.1 g/cm3(Predicted) 形态: Solid 酸度系数(pKa): 14.56±0.40(Predicted) 颜色: White to off-white ...
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While tertiary structures of state 2 had been solved with wild-type H-Ras (H-RasWT)10–13, those of state 1 were solved with M-RasWT, its P40D mutant and the T35S, G60A and Y32F mutants of H-Ras, all of which predominantly adopt state 1 in solutio10,14–17. In addition, ...
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N2 and derivative strains were maintained as described by Brenner 1974 and grown at 20°C unless otherwise indicated. Unless otherwise indicated, the reference for alleles is Riddle et al. (1997). LGI: mek-2(ku114). LGIII: mpk-1(ku1), dpy-17(e164), and unc-119(ed3). LGIV: sur-...
A cysteine-rich matricellular protein connective tissue growth factor (CTGF, also known as CCN2), a member of the CCN (Cry61, CTGF, and Nov) family, is a molecule regulating a number of biological events, such as development, wound healing, and cartinogenesis13,14. One cellular process re...