J Cell Biol 2007; 177:781-793. 21 Sun H, King AJ, Diaz HB, Marshall MS. Regulation of the protein kinase Raf-1 by oncogenic Ras through phosphati- dylinositol 3-kinase, Cdc42/Rac and Pak. Curr Biol 2000; 10:281-284. 22 Mitin N, Kudla AJ, Konieczny SF, Taparowsky EJ. ...
RAS genes are the most commonly mutated oncogenes in cancer, but effective therapeutic strategies to target RAS-mutant cancers have proved elusive. A key aspect of this challenge is the fact that direct inhibition of RAS proteins has proved difficult, le
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Wallace, and J. Granger, “Role of angiotensin II type I receptor agonistic autoantibodies (AT1-AA) in preeclampsia,” Current Opinion in Pharmacology, vol. 11, no. 2, pp. 175–179, 2011. [41] R. Dechend, C. Viedt, D. N. Müller et al., “AT1 receptor agonistic antibodies from ...
We are expanding these findings and examining additional properties of DT/siTR1 cells to better evaluate TR1 as a target for cancer therapy.doi:10.1096/fasebj.21.5.A115Min〩yuk YooXue㎝ing XuBradley A CarlsonVadim N GladyshevDolph L Hatfield...
还考虑了融合蛋白,其包含与抗体(例如,igg(1、2、3、4)、ige、igd、iga、igm及其变体)或其片段(例如,在一些实施方案中,保持与一种或多种fc受体、c1q、蛋白a、蛋白g或其任何组合的结合的片段)的恒定域连接的本公开的sctcr,并且包括免疫球蛋白重链单体和多聚体,例如fc二聚体;参见,例如,wong et al.,j.immun...
Experiments using a protein vector prepared from Pseudomonas exotoxin A (PEA) were also conducted in a manner similar to the pMV7 vector (but not set forth herein). A description of the PEA protein vector can be found in Pastan, I, and Fitzgerald, O. J. Biol Chem, 264, 15157-15160 ...
CA Cancer J Clin. 2009, 59: 225-249. 10.3322/caac.20006. Article PubMed Google Scholar Siena S, Sartore-Bianchi A, Di Nicolantonio F, et al: Biomarkers Predicting Clinical Outcome of Epidermal Growth Factor Receptor-Targeted Therapy in Metastatic Colorectal Cancer. J Natl Cancer Inst. 2009...
HumloacnaliaznadtioYne.aOstnRthAeSoDthoewr hnasntrde,atmheSmigonsat leivnigdePnattdhwiffaeyrences between the intracellular activities of the RAS proteins in the two organisms relate to RAS effectors and their downstream signaling Ascaafsocardeems.entioned, many studies have highlighted the great ...
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