[0242]TOR抑制剂包括但不限于AP‑23573、CCI‑779、依维莫司、RAD‑001、雷帕霉素、替西 罗莫司、ATP竞争性TORC1/TORC2抑制剂,包括PI‑103、PP242、PP30和Torin 1。其它TOR抑制 剂是FKBP12增强剂;雷帕霉素和其衍生物,包括CCI‑779(替西罗莫司),RAD001(依维莫司; WO 9409010)和AP23573;雷帕霉素...
Nagothu KK, Rishi AK, Jaszewski R, Kucuk O, Majumdar AP (2004) Folic acid- mediated inhibition of serum-induced activation of EGFR promoter in colon cancer cells. Am J Physiol Gastrointestinal Liver Physiol 287: 541–546. Sartore-Bianchi A, Moroni M, Veronese S, Carnaghi C, Bajetta E,...
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tgr-1202)、pi3kδ和γ抑制剂(例如cal-130)、多激酶抑制剂(例如tg02和索拉非尼(sorafenib))、激素(例如雌激素和激素激动剂,如促黄体激素释放激素(lhrh)激动剂(例如戈舍瑞林、亮丙瑞林(leuprolide)及曲普瑞林(triptorelin))、baff中和抗体(例如ly2127399)、ikk抑制剂、p38mapk抑制剂、抗il-6(例如cnt0328)、端粒酶...
1.本技术是申请日为2020年11月4日,申请号为202080091077.8,发明名称为“ras抑制剂”的发明专利申请的分案申请。 2.相关申请的交叉参考 3.本技术要求2019年11月4日提出申请的美国申请号62/930,394;2019年12月20日提出申请的美国申请号62/951,763;2020年3月26日提出申请的美国申请号63/000,375;以及2020年6月...
After blocking with 5% nonfat milk and washing with Tris-buffered saline with Tween 20 (TBST) buffer, the membranes were incubated with anti-ApoE (1:1,000, Meridian, K74180B), anti-ACE2 (1:1,000, Abcam, ab15348) or anti-MasR (1:500, proteintech, 20080–1-AP) antibodies at 4 °...
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et al. Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth. Nat. Cell Biol. 17, 1218–1227 (2015). CAS PubMed PubMed Central Google Scholar Cai, J. et al. YAP–VGLL4 antagonism defines the major physiological function of the Hippo signaling ...
MADEAP序列可以与所述抗原以外的其它抗原一起使用。在增强表达产物的稳定性以外,此融合配偶不表现出对针对构建物中的疫苗接种用抗原的免疫应答有不利影响。另外,合成融合肽可以设计成提供可以受到选择剂(诸如抗体)识别的表位。在本发明的另一个实施方案中,编码本发明中所使用的合成肽翻译起始位点的核酸是符合Kozak翻译...
Diefenbacher1, Anastasia Mylona2, Olivier Kassel3 & Axel Behrens1,4 The c-Jun/AP-1 transcription factor controls key cellular behaviours, including proliferation and apoptosis, in response to JNK and Ras/MAPK signalling. While the JNK pathway has been well characterized, the mechanism of ...