3 de Langen AJ, Johnson ML, Mazieres J,et al.Sotorasib versus docetaxel for previously treated non-small-cell lung cancer with KRASG12C mutation: a randomised, open-label, phase 3 trial. Lancet, 2023, 401(10378):...
AD具有学习和记忆缺陷的特征,这与海马区突触的结构和功能损伤密切相关[1],如突触的丢失[2]、神经元形态[3]和突触蛋白的改变[4],进而破坏了突触的传递和可塑性[5]。突触缺陷是该病症认知功能障碍的病理学基础,深入认识突触结构和功能...
Východ měsíce16:48 Dorůstající Měsíc Západ měsíce4:20 so 12 Slunečno 29°/23° 2% SSV 29 km/h so 12 | Den 29° 2% Většinou jasno. Nejvyšší teploty 29 ° C. Vítr SSV o rychlosti 25 - 40 km/h. Vlhkost51% UV index10 z 11 Východ slunce5:1...
(6-FAM/ZEN/3′ IBFQ): Rn00566329_m1; rat Ccn2 (6-FAM/ZEN/3′ IBFQ): Rn01537279_g1; rat Actb1 (VIC-MGB): Rn00667869_m1; dog Ccn1 (6-FAM/ZEN/3′ IBFQ): AJX01BF; dog Ankrd1 (6-FAM/ZEN/3′ IBFQ): Cf02662722_m1; dog Ccn2 (6-FAM/ZEN/3′ IBFQ): Cf02641589_m1;...
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TheNF2tumor suppressor merlin interacts with Ras and RasGAP, which may modulate Ras signaling Yan Cui, Susann Groth, Scott Troutman, Annemarie Carlstedt, Tobias Sperka, Lars Björn Riecken, Joseph L. Kissil, Hongchuan Jin& Helen Morrison ...
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Leng X, Cooney AJ, Tsai SY, Tsai MJ: Molecular mechanisms of COUP-TF-mediated transcriptional repression: evidence for transrepression and active repression. Mol Cell Biol. 1996, 16: 2332-2340. Article PubMed Central CAS PubMed Google Scholar Aranda A, Pascual A: Nuclear hormone receptors an...
(blue). R-Ras also limits excessive, nonproductive endothelial sprouting, and block the VEGF-induced disruption of adherens junction (AJ) to maintain endothelial barrier integrity (Sawada et al.11). Thus, the VEGF and R-Ras pathways are complementary to each other to generate functional blood ...
19. Soucek L, Whitfield J, Martins CP, Finch AJ, Murphy DJ, Sodir NM et al. Modelling Myc inhibition as a cancer therapy. Nature 2008; 455: 679–683. 20. Littlewood TD, Hancock DC, Danielian PS, Parker MG, Evan GI. A modified oestrogen receptor ligand-binding domain as an improved...