在刚接触RSA的时候,会混淆RSA加密解密和RSA加签验签的概念。简单来说加密解密是公钥加密私钥解密,持有公钥(多人持有)可以对数据加密,但是只有持有私钥(一人持有)才可以解密并查看数据;加签验签是私钥加签公钥验签,持有私钥(一人持有)可以加签,持有公钥(多人持有)可以验签。 在金融行业在设计到数据交互传输的时候,需要考虑数
By this mechanism, RasGRFs regulate other Cdc42-mediated cellular processes such as the formation of actin spikes, transformation and invasion in vitro and in vivo. These results demonstrate a role for RasGRF GEFs as negative regulators of Cdc42 activation. This is a preview of subscription ...
RAS activation is triggered by various extracellular stimuli, with the primary mechanism involving the formation of complexes comprising autophosphorylated growth factor receptors, the adapter protein GRB2 and the exchange factor SOS.71It has been proposed that RAS dimerization plays a critical role in ...
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15.Buday L, Downward J. Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor.Cell. 1993;73:611-620.[PubMed] 16.Brink M, de Goeij AF, Weijenberg MP, Roemen GM, Lentjes MH, Pachen MM, Smits ...
Tsao, B. Wegrzynski, S.D. Emerson, D.C. Fry Characterization of a 78-residue fragment of c-Raf-1 that comprises a minimal binding domain for the interaction with Ras-GTP J. biol. Chem., 269 (1994), pp. 22,340-22,346 Google Scholar Scheffzek et al., 1995 K. Scheffzek, C. ...
Download: Download high-res image (406KB) Download: Download full-size image Fig. 1. Modulation of hypertrophic remodeling of NCRM by Ras mutants. A. Expression of Ras proteins in transduced NRCM. Representative immunoblot showing expression of H-Ras protein in NRCM transduced for 48 h with rel...
(K-ras, N-ras and H-ras), the Raf isoforms c-Raf-1, Raf-A and Raf-B, the MEKs MEK1 and MEK2, the Ras GTPase-activating proteins GAP-1 and NF1, the Ras guanine nucleotide-releasing factors RasGRF1 and RasGRF2, and the adaptor proteins Sos1, Grb2 and Shc [1, 4, 13–24]...
2016;16(6):399–406. doi:10.1007/s40256-016-0185-0 (Open in a new window)PubMed(Open in a new window)Google Scholar Dézsi CA. The different therapeutic choices with ARBs. Which one to give? When? Why? Am J Cardiovasc Drugs. 2016;16(4):255–266. doi:10.1007/s40256-016-0165...